1q5f
From Proteopedia
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| - | [[Image:1q5f.jpg|left|200px]] | + | [[Image:1q5f.jpg|left|200px]] |
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| - | '''NMR Structure of Type IVb pilin (PilS) from Salmonella typhi''' | + | {{Structure |
| + | |PDB= 1q5f |SIZE=350|CAPTION= <scene name='initialview01'>1q5f</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= PilS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=601 Salmonella typhi]) | ||
| + | }} | ||
| + | |||
| + | '''NMR Structure of Type IVb pilin (PilS) from Salmonella typhi''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1Q5F is a [ | + | 1Q5F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhi Salmonella typhi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q5F OCA]. |
==Reference== | ==Reference== | ||
| - | NMR structure of a type IVb pilin from Salmonella typhi and its assembly into pilus., Xu XF, Tan YW, Lam L, Hackett J, Zhang M, Mok YK, J Biol Chem. 2004 Jul 23;279(30):31599-605. Epub 2004 May 24. PMID:[http:// | + | NMR structure of a type IVb pilin from Salmonella typhi and its assembly into pilus., Xu XF, Tan YW, Lam L, Hackett J, Zhang M, Mok YK, J Biol Chem. 2004 Jul 23;279(30):31599-605. Epub 2004 May 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15159389 15159389] |
[[Category: Salmonella typhi]] | [[Category: Salmonella typhi]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: type ivb pilin]] | [[Category: type ivb pilin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:33:14 2008'' |
Revision as of 11:33, 20 March 2008
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| Gene: | PilS (Salmonella typhi) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR Structure of Type IVb pilin (PilS) from Salmonella typhi
Overview
The structure of the N-terminal-truncated Type IVb structural pilin (t-PilS) from Salmonella typhi was determined by NMR. Although topologically similar to the recently determined x-ray structure of pilin from Vibrio cholerae toxin-coregulated pilus, the only Type IVb pilin with known structure, t-PilS contains many distinct structural features. The protein contains an extra pair of beta-strands in the N-terminal alphabeta loop that align with the major beta-strands to form a continuous 7-stranded antiparallel beta-sheet. The C-terminal disulfide-bonded region of t-PilS is only half the length of that of toxin-coregulated pilus pilin. A model of S. typhi pilus has been proposed and mutagenesis studies suggested that residues on both the alphabeta loop and the C-terminal disulfide-bonded region of PilS might be involved in binding specificity of the pilus. This model structure reveals an exposed surface between adjacent subunits of PilS that could be a potential binding site for the cystic fibrosis transmembrane conductance regulator.
About this Structure
1Q5F is a Single protein structure of sequence from Salmonella typhi. Full crystallographic information is available from OCA.
Reference
NMR structure of a type IVb pilin from Salmonella typhi and its assembly into pilus., Xu XF, Tan YW, Lam L, Hackett J, Zhang M, Mok YK, J Biol Chem. 2004 Jul 23;279(30):31599-605. Epub 2004 May 24. PMID:15159389
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