Structural highlights
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
A series of 3-aryl-4-(arylhydrazono)-1H-pyrazol-5-one inhibitors of GSK3beta was developed from a low molecular weight, highly ligand efficient screening hit 1. Hit-to-lead optimization led to a number of highly potent inhibitors, while maintaining the high ligand efficiency of the screening hit.
3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3beta.,Arnost M, Pierce A, ter Haar E, Lauffer D, Madden J, Tanner K, Green J Bioorg Med Chem Lett. 2010 Mar 1;20(5):1661-4. Epub 2010 Jan 21. PMID:20138514[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Arnost M, Pierce A, ter Haar E, Lauffer D, Madden J, Tanner K, Green J. 3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3beta. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1661-4. Epub 2010 Jan 21. PMID:20138514 doi:10.1016/j.bmcl.2010.01.072
