1q68
From Proteopedia
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| - | [[Image:1q68.gif|left|200px]]< | + | [[Image:1q68.gif|left|200px]] |
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| - | '''Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase LCK fragments''' | + | {{Structure |
| + | |PDB= 1q68 |SIZE=350|CAPTION= <scene name='initialview01'>1q68</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= CD4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), LCK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase LCK fragments''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==Disease== | ==Disease== | ||
| - | Known | + | Known disease associated with this structure: SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]] |
==About this Structure== | ==About this Structure== | ||
| - | 1Q68 is a [ | + | 1Q68 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q68 OCA]. |
==Reference== | ==Reference== | ||
| - | A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8., Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ, Science. 2003 Sep 19;301(5640):1725-8. PMID:[http:// | + | A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8., Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ, Science. 2003 Sep 19;301(5640):1725-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14500983 14500983] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: zinc coordination]] | [[Category: zinc coordination]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:33:30 2008'' |
Revision as of 11:33, 20 March 2008
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| Ligands: | |||||||
| Gene: | CD4 (Homo sapiens), LCK (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase LCK fragments
Contents |
Overview
The T cell coreceptors CD4 and CD8 both associate via their cytoplasmic tails with the N-terminus of the Src-family tyrosine kinase Lck. These interactions require zinc and are critical for T cell development and activation. We examined the folding and solution structures of ternary CD4-Lck-Zn2+ and CD8alpha-Lck-Zn2+ complexes. The coreceptor tails and the Lck N-terminus are unstructured in isolation but assemble in the presence of zinc to form compactly folded heterodimeric domains. The cofolded complexes have similar "zinc clasp" cores that are augmented by distinct structural elements. A dileucine motif required for clathrin-mediated endocytosis of CD4 is masked by Lck.
Disease
Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]
About this Structure
1Q68 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8., Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ, Science. 2003 Sep 19;301(5640):1725-8. PMID:14500983
Page seeded by OCA on Thu Mar 20 13:33:30 2008
