3izz
From Proteopedia
(Difference between revisions)
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| - | + | ==Models for ribosome components that are nearest neighbors to the bovine mitochondrial initiation factor2 bound to the E. Coli ribosome== | |
| - | + | <StructureSection load='3izz' size='340' side='right' caption='[[3izz]], [[Resolution|resolution]] 10.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3izz]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IZZ FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3izy|3izy]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3izz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3izz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3izz RCSB], [http://www.ebi.ac.uk/pdbsum/3izz PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Mitochondria have their own translational machineries for the synthesis of thirteen polypeptide chains that are components of the complexes that participate in the process of oxidative phosphorylation (or ATP generation). Translation initiation in mammalian mitochondria requires two initiation factors, IF2(mt) and IF3(mt), instead of the three that are present in eubacteria. The mammalian IF2(mt) possesses a unique 37 amino acid insertion domain, which is known to be important for the formation of the translation initiation complex. We have obtained a three-dimensional cryoelectron microscopic map of the mammalian IF2(mt) in complex with initiator and the eubacterial ribosome. We find that the 37 amino acid insertion domain interacts with the same binding site on the ribosome that would be occupied by the eubacterial initiation factor IF1, which is absent in mitochondria. Our finding suggests that the insertion domain of IF2(mt) mimics the function of eubacterial IF1, by blocking the ribosomal aminoacyl-tRNA binding site (A site) at the initiation step. | ||
| - | + | Insertion domain within mammalian mitochondrial translation initiation factor 2 serves the role of eubacterial initiation factor 1.,Yassin AS, Haque ME, Datta PP, Elmore K, Banavali NK, Spremulli LL, Agrawal RK Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):3918-23. Epub 2011 Feb 22. PMID:21368145<ref>PMID:21368145</ref> | |
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| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | < | + | </div> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Agrawal, R K | + | [[Category: Agrawal, R K]] |
| - | [[Category: Banavali, N K | + | [[Category: Banavali, N K]] |
| - | [[Category: Datta, P P | + | [[Category: Datta, P P]] |
| - | [[Category: Elmore, K | + | [[Category: Elmore, K]] |
| - | [[Category: Haque, E | + | [[Category: Haque, E]] |
| - | [[Category: Spremulli, L L | + | [[Category: Spremulli, L L]] |
| - | [[Category: Yassin, A S | + | [[Category: Yassin, A S]] |
| - | + | ||
[[Category: Ribosomal protein]] | [[Category: Ribosomal protein]] | ||
[[Category: Rna]] | [[Category: Rna]] | ||
Revision as of 14:56, 18 December 2014
Models for ribosome components that are nearest neighbors to the bovine mitochondrial initiation factor2 bound to the E. Coli ribosome
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