1q9o
From Proteopedia
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| - | [[Image:1q9o.jpg|left|200px]] | + | [[Image:1q9o.jpg|left|200px]] |
| - | + | ||
| - | '''S45-18 Fab Unliganded''' | + | {{Structure |
| + | |PDB= 1q9o |SIZE=350|CAPTION= <scene name='initialview01'>1q9o</scene>, resolution 1.79Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''S45-18 Fab Unliganded''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1Q9O is a [ | + | 1Q9O is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q9O OCA]. |
==Reference== | ==Reference== | ||
| - | Germline antibody recognition of distinct carbohydrate epitopes., Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV, Nat Struct Biol. 2003 Dec;10(12):1019-25. Epub 2003 Nov 16. PMID:[http:// | + | Germline antibody recognition of distinct carbohydrate epitopes., Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV, Nat Struct Biol. 2003 Dec;10(12):1019-25. Epub 2003 Nov 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14625588 14625588] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: MG]] | [[Category: MG]] | ||
[[Category: anti-carbohydrate]] | [[Category: anti-carbohydrate]] | ||
| - | [[Category: anti- | + | [[Category: anti-lp]] |
[[Category: antibody]] | [[Category: antibody]] | ||
[[Category: antigen-binding fragment]] | [[Category: antigen-binding fragment]] | ||
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[[Category: immunoglobulin]] | [[Category: immunoglobulin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:34:47 2008'' |
Revision as of 11:34, 20 March 2008
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| , resolution 1.79Å | |||||||
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| Ligands: | |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
S45-18 Fab Unliganded
Overview
High-resolution structures reveal how a germline antibody can recognize a range of clinically relevant carbohydrate epitopes. The germline response to a carbohydrate immunogen can be critical to survivability, with selection for antibody gene segments that both confer protection against common pathogens and retain the flexibility to adapt to new disease organisms. We show here that antibody S25-2 binds several distinct inner-core epitopes of bacterial lipopolysaccharides (LPSs) by linking an inherited monosaccharide residue binding site with a subset of complementarity-determining regions (CDRs) of limited flexibility positioned to recognize the remainder of an array of different epitopes. This strategy allows germline antibodies to adapt to different epitopes while minimizing entropic penalties associated with the immobilization of labile CDRs upon binding of antigen, and provides insight into the link between the genetic origin of individual CDRs and their respective roles in antigen recognition.
About this Structure
1Q9O is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Germline antibody recognition of distinct carbohydrate epitopes., Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV, Nat Struct Biol. 2003 Dec;10(12):1019-25. Epub 2003 Nov 16. PMID:14625588
Page seeded by OCA on Thu Mar 20 13:34:47 2008
Categories: Mus musculus | Protein complex | Brade, H. | Brade, L. | Evans, S V. | Kosma, P. | MacKenzie, C R. | Nguyen, H P. | Seto, N O. | MG | Anti-carbohydrate | Anti-lp | Antibody | Antigen-binding fragment | Fab | Immunoglobulin
