3juv

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m (Protected "3juv" [edit=sysop:move=sysop])
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{{STRUCTURE_3juv| PDB=3juv | SCENE= }}
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==Crystal structure of human lanosterol 14alpha-demethylase (CYP51)==
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===Crystal structure of human lanosterol 14alpha-demethylase (CYP51)===
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<StructureSection load='3juv' size='340' side='right' caption='[[3juv]], [[Resolution|resolution]] 3.12&Aring;' scene=''>
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{{ABSTRACT_PUBMED_020149798}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3juv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JUV FirstGlance]. <br>
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==Function==
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCD:BETA-CYCLODEXTRIN'>BCD</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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[[http://www.uniprot.org/uniprot/CP51A_HUMAN CP51A_HUMAN]] Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3i3k|3i3k]], [[3jus|3jus]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP51, CYP51A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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==About this Structure==
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>
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[[3juv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUV OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3juv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3juv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3juv RCSB], [http://www.ebi.ac.uk/pdbsum/3juv PDBsum]</span></td></tr>
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</table>
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==Reference==
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== Evolutionary Conservation ==
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<ref group="xtra">PMID:020149798</ref><references group="xtra"/><references/>
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/3juv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Sterol 14-demethylase]]
[[Category: Sterol 14-demethylase]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C.]]
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[[Category: Bountra, C]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards, A M]]
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[[Category: MacKenzie, F.]]
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[[Category: MacKenzie, F]]
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[[Category: Park, H.]]
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[[Category: Park, H]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Structural genomic]]
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[[Category: Strushkevich, N.]]
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[[Category: Strushkevich, N]]
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[[Category: Usanov, S A.]]
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[[Category: Usanov, S A]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt, J]]
[[Category: Cholesterol biosynthesis]]
[[Category: Cholesterol biosynthesis]]
[[Category: Cytochrome p450]]
[[Category: Cytochrome p450]]
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[[Category: Sterol 14alpha-demethylase]]
[[Category: Sterol 14alpha-demethylase]]
[[Category: Sterol biosynthesis]]
[[Category: Sterol biosynthesis]]
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[[Category: Structural genomic]]
 
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[[Category: Structural genomics consortium]]
 
[[Category: Transmembrane]]
[[Category: Transmembrane]]

Revision as of 15:18, 18 December 2014

Crystal structure of human lanosterol 14alpha-demethylase (CYP51)

3juv, resolution 3.12Å

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