1q9v

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[[Image:1q9v.gif|left|200px]]<br /><applet load="1q9v" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1q9v.gif|left|200px]]
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caption="1q9v, resolution 1.73&Aring;" />
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'''S25-2- Kdo monosaccharide complex'''<br />
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{{Structure
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|PDB= 1q9v |SIZE=350|CAPTION= <scene name='initialview01'>1q9v</scene>, resolution 1.73&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''S25-2- Kdo monosaccharide complex'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1Q9V is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=KDO:'>KDO</scene>, <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q9V OCA].
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1Q9V is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q9V OCA].
==Reference==
==Reference==
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Germline antibody recognition of distinct carbohydrate epitopes., Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV, Nat Struct Biol. 2003 Dec;10(12):1019-25. Epub 2003 Nov 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14625588 14625588]
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Germline antibody recognition of distinct carbohydrate epitopes., Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV, Nat Struct Biol. 2003 Dec;10(12):1019-25. Epub 2003 Nov 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14625588 14625588]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: ZN]]
[[Category: ZN]]
[[Category: anti-carbohydrate]]
[[Category: anti-carbohydrate]]
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[[Category: anti-lps]]
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[[Category: anti-lp]]
[[Category: antibody]]
[[Category: antibody]]
[[Category: antigen-binding fragment]]
[[Category: antigen-binding fragment]]
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[[Category: protein-carbohydrate complex]]
[[Category: protein-carbohydrate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:37:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:34:51 2008''

Revision as of 11:34, 20 March 2008

Image:1q9v.gif


PDB ID 1q9v

Drag the structure with the mouse to rotate
, resolution 1.73Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



S25-2- Kdo monosaccharide complex


Overview

High-resolution structures reveal how a germline antibody can recognize a range of clinically relevant carbohydrate epitopes. The germline response to a carbohydrate immunogen can be critical to survivability, with selection for antibody gene segments that both confer protection against common pathogens and retain the flexibility to adapt to new disease organisms. We show here that antibody S25-2 binds several distinct inner-core epitopes of bacterial lipopolysaccharides (LPSs) by linking an inherited monosaccharide residue binding site with a subset of complementarity-determining regions (CDRs) of limited flexibility positioned to recognize the remainder of an array of different epitopes. This strategy allows germline antibodies to adapt to different epitopes while minimizing entropic penalties associated with the immobilization of labile CDRs upon binding of antigen, and provides insight into the link between the genetic origin of individual CDRs and their respective roles in antigen recognition.

About this Structure

1Q9V is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Germline antibody recognition of distinct carbohydrate epitopes., Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV, Nat Struct Biol. 2003 Dec;10(12):1019-25. Epub 2003 Nov 16. PMID:14625588

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