3n1r

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3n1r" [edit=sysop:move=sysop])
Line 1: Line 1:
-
{{STRUCTURE_3n1r| PDB=3n1r | SCENE= }}
+
==Crystal Structure of ShhN==
-
===Crystal Structure of ShhN===
+
<StructureSection load='3n1r' size='340' side='right' caption='[[3n1r]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
-
{{ABSTRACT_PUBMED_020519495}}
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[3n1r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N1R FirstGlance]. <br>
-
==Function==
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
[[http://www.uniprot.org/uniprot/SHH_MOUSE SHH_MOUSE]] Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction (By similarity).<ref>PMID:7736596</ref>
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3d1m|3d1m]], [[3n1f|3n1f]], [[3n1g|3n1g]], [[3n1m|3n1m]], [[3n1o|3n1o]], [[3n1p|3n1p]], [[3n1q|3n1q]], [[1vhh|1vhh]]</td></tr>
-
 
+
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Shh, Hhg1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n1r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n1r RCSB], [http://www.ebi.ac.uk/pdbsum/3n1r PDBsum]</span></td></tr>
-
[[3n1r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1R OCA].
+
</table>
-
 
+
== Evolutionary Conservation ==
-
==Reference==
+
[[Image:Consurf_key_small.gif|200px|right]]
-
<ref group="xtra">PMID:020519495</ref><references group="xtra"/><references/>
+
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n1/3n1r_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Kavran, J M.]]
+
[[Category: Kavran, J M]]
-
[[Category: Leahy, D J.]]
+
[[Category: Leahy, D J]]
[[Category: Binding site]]
[[Category: Binding site]]
[[Category: Cell adhesion molecule]]
[[Category: Cell adhesion molecule]]

Revision as of 15:31, 18 December 2014

Crystal Structure of ShhN

3n1r, resolution 2.13Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3n1r"
Personal tools