3kuq

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{{STRUCTURE_3kuq| PDB=3kuq | SCENE= }}
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==Crystal structure of the DLC1 RhoGAP domain==
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===Crystal structure of the DLC1 RhoGAP domain===
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<StructureSection load='3kuq' size='340' side='right' caption='[[3kuq]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3kuq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KUQ FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/RHG07_HUMAN RHG07_HUMAN]] Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.<ref>PMID:18786931</ref> <ref>PMID:19170769</ref> <ref>PMID:19710422</ref>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DLC1, ARHGAP7, KIAA1723, STARD12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kuq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kuq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kuq RCSB], [http://www.ebi.ac.uk/pdbsum/3kuq PDBsum]</span></td></tr>
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[[3kuq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUQ OCA].
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</table>
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== Evolutionary Conservation ==
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==Reference==
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[[Image:Consurf_key_small.gif|200px|right]]
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<references group="xtra"/><references/>
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ku/3kuq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev, A]]
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[[Category: Bountra, C.]]
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[[Category: Bountra, C]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards, A M]]
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[[Category: MacKenzie, F.]]
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[[Category: MacKenzie, F]]
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[[Category: Nedyalkova, L.]]
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[[Category: Nedyalkova, L]]
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[[Category: Park, H.]]
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[[Category: Park, H]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Structural genomic]]
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[[Category: Shen, L.]]
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[[Category: Shen, L]]
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[[Category: Tempel, W.]]
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[[Category: Tempel, W]]
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[[Category: Tong, Y.]]
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[[Category: Tong, Y]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt, J]]
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[[Category: Zhong, N.]]
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[[Category: Zhong, N]]
[[Category: Gtpase activation]]
[[Category: Gtpase activation]]
[[Category: Hydrolase activator]]
[[Category: Hydrolase activator]]
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Sgc]]
[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
 

Revision as of 15:43, 18 December 2014

Crystal structure of the DLC1 RhoGAP domain

3kuq, resolution 2.30Å

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