3h2v

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{{STRUCTURE_3h2v| PDB=3h2v | SCENE= }}
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==Human raver1 RRM1 domain in complex with human vinculin tail domain Vt==
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===Human raver1 RRM1 domain in complex with human vinculin tail domain Vt===
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<StructureSection load='3h2v' size='340' side='right' caption='[[3h2v]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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{{ABSTRACT_PUBMED_19523901}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3h2v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H2V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H2V FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rke|1rke]], [[1tr2|1tr2]], [[3h2u|3h2u]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RAVER1, KIAA1978 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h2v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h2v RCSB], [http://www.ebi.ac.uk/pdbsum/3h2v PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h2/3h2v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The translational machinery of the cell relocalizes to focal adhesions following the activation of integrin receptors. This response allows for rapid, local production of components needed for adhesion complex assembly and signaling. Vinculin links focal adhesions to the actin cytoskeleton following its activation by integrin signaling, which severs intramolecular interactions of vinculin's head and tail (Vt) domains. Our vinculin:raver1 crystal structures and binding studies show that activated Vt selectively interacts with one of the three RNA recognition motifs of raver1, that the vinculin:raver1 complex binds to F-actin, and that raver1 binds selectively to RNA, including a sequence found in vinculin mRNA. Further, mutation of residues that mediate interaction of raver1 with vinculin abolish their colocalization in cells. These findings suggest a feed-forward model where vinculin activation at focal adhesions provides a scaffold for recruitment of raver1 and its mRNA cargo to facilitate the production of components of adhesion complexes.
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==Function==
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Raver1 interactions with vinculin and RNA suggest a feed-forward pathway in directing mRNA to focal adhesions.,Lee JH, Rangarajan ES, Yogesha SD, Izard T Structure. 2009 Jun 10;17(6):833-42. PMID:19523901<ref>PMID:19523901</ref>
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[[http://www.uniprot.org/uniprot/RAVR1_HUMAN RAVR1_HUMAN]] Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity).
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[3h2v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H2V OCA].
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</div>
==See Also==
==See Also==
*[[Vinculin|Vinculin]]
*[[Vinculin|Vinculin]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019523901</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Izard, T.]]
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[[Category: Izard, T]]
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[[Category: Lee, J H.]]
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[[Category: Lee, J H]]
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[[Category: Rangarajan, E S.]]
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[[Category: Rangarajan, E S]]
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[[Category: Yogesha, S D.]]
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[[Category: Yogesha, S D]]
[[Category: Actin cytoskeleton]]
[[Category: Actin cytoskeleton]]
[[Category: Cell adhesion]]
[[Category: Cell adhesion]]

Revision as of 15:44, 18 December 2014

Human raver1 RRM1 domain in complex with human vinculin tail domain Vt

3h2v, resolution 2.90Å

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