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1qf4

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[[Image:1qf4.jpg|left|200px]]<br /><applet load="1qf4" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1qf4.jpg|left|200px]]
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caption="1qf4, resolution 2.2&Aring;" />
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'''DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE'''<br />
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{{Structure
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|PDB= 1qf4 |SIZE=350|CAPTION= <scene name='initialview01'>1qf4</scene>, resolution 2.2&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene> and <scene name='pdbligand=RPD:(C8-R)-HYDANTOCIDIN 5'-PHOSPHATE'>RPD</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4]
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|GENE=
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}}
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'''DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1QF4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=GDP:'>GDP</scene> and <scene name='pdbligand=RPD:'>RPD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QF4 OCA].
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1QF4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QF4 OCA].
==Reference==
==Reference==
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An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase., Hanessian S, Lu PP, Sanceau JY, Chemla P, Gohda K, Fonne-Pfister R, Prade L, Cowan-Jacob SW, Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3159-3162. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10556888 10556888]
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An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase., Hanessian S, Lu PP, Sanceau JY, Chemla P, Gohda K, Fonne-Pfister R, Prade L, Cowan-Jacob SW, Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3159-3162. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10556888 10556888]
[[Category: Adenylosuccinate synthase]]
[[Category: Adenylosuccinate synthase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: RPD]]
[[Category: RPD]]
[[Category: gtp-binding]]
[[Category: gtp-binding]]
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[[Category: gtp-hydrolysing enzymes]]
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[[Category: gtp-hydrolysing enzyme]]
[[Category: purine biosynthesis]]
[[Category: purine biosynthesis]]
[[Category: synthetase]]
[[Category: synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:38:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:36:36 2008''

Revision as of 11:36, 20 March 2008

Image:1qf4.jpg


PDB ID 1qf4

Drag the structure with the mouse to rotate
, resolution 2.2Å
Ligands: , , and
Activity: Adenylosuccinate synthase, with EC number 6.3.4.4
Coordinates: save as pdb, mmCIF, xml



DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE


Overview

Two relatively weak herbicides, hydantocidin phosphate and hadacidin were linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is shown) of the enzyme adenylosuccinate synthetase. The crystal structures of the bisubstrate-enzyme complexes were determined.

About this Structure

1QF4 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase., Hanessian S, Lu PP, Sanceau JY, Chemla P, Gohda K, Fonne-Pfister R, Prade L, Cowan-Jacob SW, Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3159-3162. PMID:10556888

Page seeded by OCA on Thu Mar 20 13:36:36 2008

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