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3m4t

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{{STRUCTURE_3m4t| PDB=3m4t | SCENE= }}
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==Crystal structure of the BTB domain from Kaiso/ZBTB33, form I==
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===Crystal structure of the BTB domain from Kaiso/ZBTB33, form I===
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<StructureSection load='3m4t' size='340' side='right' caption='[[3m4t]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3m4t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M4T FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/KAISO_HUMAN KAISO_HUMAN]] Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.<ref>PMID:11445535</ref> <ref>PMID:14527417</ref> <ref>PMID:15548582</ref> <ref>PMID:15817151</ref>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3m8v|3m8v]]</td></tr>
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==About this Structure==
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KAISO, ZBTB33, ZNF348 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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[[3m4t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4T OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m4t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m4t RCSB], [http://www.ebi.ac.uk/pdbsum/3m4t PDBsum]</span></td></tr>
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</table>
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==Reference==
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__TOC__
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<references group="xtra"/><references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, L.]]
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[[Category: Chen, L]]
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[[Category: Prive, G G.]]
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[[Category: Prive, G G]]
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[[Category: Stogios, P J.]]
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[[Category: Stogios, P J]]
[[Category: Activator]]
[[Category: Activator]]
[[Category: Btb domain]]
[[Category: Btb domain]]

Revision as of 16:33, 18 December 2014

Crystal structure of the BTB domain from Kaiso/ZBTB33, form I

3m4t, resolution 2.05Å

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