3n2i

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{{STRUCTURE_3n2i| PDB=3n2i | SCENE= }}
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==2.25 Angstrom resolution crystal structure of a thymidylate kinase (tmk) from Vibrio cholerae O1 biovar eltor str. N16961 in complex with thymidine==
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===2.25 Angstrom resolution crystal structure of a thymidylate kinase (tmk) from Vibrio cholerae O1 biovar eltor str. N16961 in complex with thymidine===
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<StructureSection load='3n2i' size='340' side='right' caption='[[3n2i]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3n2i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae_o1_biovar_el_tor Vibrio cholerae o1 biovar el tor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N2I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N2I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lv8|3lv8]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tmk, VC_2016 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=686 Vibrio cholerae O1 biovar El Tor])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n2i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n2i RCSB], [http://www.ebi.ac.uk/pdbsum/3n2i PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n2/3n2i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/KTHY_VIBCH KTHY_VIBCH]] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).
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*[[Thymidylate kinase|Thymidylate kinase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3n2i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae_o1_biovar_el_tor Vibrio cholerae o1 biovar el tor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N2I OCA].
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[[Category: Vibrio cholerae o1 biovar el tor]]
[[Category: Vibrio cholerae o1 biovar el tor]]
[[Category: DTMP kinase]]
[[Category: DTMP kinase]]
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[[Category: Anderson, W F.]]
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[[Category: Anderson, W F]]
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[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
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[[Category: Structural genomic]]
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[[Category: Dubrovska, I.]]
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[[Category: Dubrovska, I]]
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[[Category: Halavaty, A S.]]
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[[Category: Halavaty, A S]]
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[[Category: Minasov, G.]]
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[[Category: Minasov, G]]
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[[Category: Peterson, S.]]
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[[Category: Peterson, S]]
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[[Category: Shuvalova, L.]]
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[[Category: Shuvalova, L]]
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[[Category: Winsor, J.]]
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[[Category: Winsor, J]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
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[[Category: Center for structural genomics of infectious disease]]
 
[[Category: Csgid]]
[[Category: Csgid]]
[[Category: Infectious disease]]
[[Category: Infectious disease]]
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[[Category: Nucleotide biosynthesis]]
[[Category: Nucleotide biosynthesis]]
[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
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[[Category: Structural genomic]]
 
[[Category: Thymidylate kinase]]
[[Category: Thymidylate kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Vibrio cholerae]]
[[Category: Vibrio cholerae]]

Revision as of 16:47, 18 December 2014

2.25 Angstrom resolution crystal structure of a thymidylate kinase (tmk) from Vibrio cholerae O1 biovar eltor str. N16961 in complex with thymidine

3n2i, resolution 2.25Å

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