3kln

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{{STRUCTURE_3kln| PDB=3kln | SCENE= }}
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==Vibrio cholerae VpsT==
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===Vibrio cholerae VpsT===
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<StructureSection load='3kln' size='340' side='right' caption='[[3kln]], [[Resolution|resolution]] 3.08&Aring;' scene=''>
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{{ABSTRACT_PUBMED_20150502}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3kln]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KLN FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3klo|3klo]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VCA0952, VC_A0952 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=666 Vibrio cholerae])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kln OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kln RCSB], [http://www.ebi.ac.uk/pdbsum/3kln PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/3kln_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Microorganisms can switch from a planktonic, free-swimming life-style to a sessile, colonial state, called a biofilm, which confers resistance to environmental stress. Conversion between the motile and biofilm life-styles has been attributed to increased levels of the prokaryotic second messenger cyclic di-guanosine monophosphate (c-di-GMP), yet the signaling mechanisms mediating such a global switch are poorly understood. Here we show that the transcriptional regulator VpsT from Vibrio cholerae directly senses c-di-GMP to inversely control extracellular matrix production and motility, which identifies VpsT as a master regulator for biofilm formation. Rather than being regulated by phosphorylation, VpsT undergoes a change in oligomerization on c-di-GMP binding.
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==About this Structure==
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Vibrio cholerae VpsT regulates matrix production and motility by directly sensing cyclic di-GMP.,Krasteva PV, Fong JC, Shikuma NJ, Beyhan S, Navarro MV, Yildiz FH, Sondermann H Science. 2010 Feb 12;327(5967):866-8. PMID:20150502<ref>PMID:20150502</ref>
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[[3kln]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLN OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:020150502</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Vibrio cholerae]]
[[Category: Vibrio cholerae]]
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[[Category: Krasteva, P V.]]
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[[Category: Krasteva, P V]]
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[[Category: Navarro, V A.S.]]
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[[Category: Navarro, V A.S]]
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[[Category: Sondermann, H.]]
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[[Category: Sondermann, H]]
[[Category: Dna-binding]]
[[Category: Dna-binding]]
[[Category: Hth domain]]
[[Category: Hth domain]]

Revision as of 16:52, 18 December 2014

Vibrio cholerae VpsT

3kln, resolution 3.08Å

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