1qke
From Proteopedia
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| - | [[Image:1qke.jpg|left|200px]] | + | [[Image:1qke.jpg|left|200px]] |
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| - | '''ERABUTOXIN''' | + | {{Structure |
| + | |PDB= 1qke |SIZE=350|CAPTION= <scene name='initialview01'>1qke</scene>, resolution 1.5Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''ERABUTOXIN''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QKE is a [ | + | 1QKE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Laticauda_semifasciata Laticauda semifasciata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKE OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of dimeric and monomeric erabutoxin a refined at 1.5 A resolution., Nastopoulos V, Kanellopoulos PN, Tsernoglou D, Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):964-74. PMID:[http:// | + | Structure of dimeric and monomeric erabutoxin a refined at 1.5 A resolution., Nastopoulos V, Kanellopoulos PN, Tsernoglou D, Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):964-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9757111 9757111] |
[[Category: Laticauda semifasciata]] | [[Category: Laticauda semifasciata]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: neurotoxin]] | [[Category: neurotoxin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:38:51 2008'' |
Revision as of 11:38, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
ERABUTOXIN
Overview
Erabutoxin a has been crystallized in its monomeric and dimeric forms. The structures were refined at 1.50 and 1.49 A resolution, respectively, using synchrotron radiation data. The crystals belong to space group P212121, with cell dimensions a = 49.84, b = 46.62, c = 21.22 A for the monomer and a = 55.32, b = 53.54, c = 40.76 A for the dimer. Using starting models from earlier structure determinations, the monomeric structure refined to an R value of 16.7% (8004 unique reflections, 17.0-1.50 A resolution range), while the dimeric structure has been solved by the molecular-replacement method with a final R value of 16.9% (19 444 unique reflections, 17.4-1.49 A resolution range). The high-resolution electron-density maps clearly revealed significant discrete disorder in the proteins and allowed an accurate determination of the solvent structure. For the monomer, the side chains of six residues were modelled with alternate conformers and 106 sites for water molecules and one site for a sulfate ion were included in the final model, whereas for the dimer, 206 sites for water molecules were included and both C-terminal residues together with the side chains of 11 residues adopted alternative conformations. A comparison was made with earlier structure determinations. The features of the solvent structure of the erabutoxin molecules are discussed in detail.
About this Structure
1QKE is a Single protein structure of sequence from Laticauda semifasciata. Full crystallographic information is available from OCA.
Reference
Structure of dimeric and monomeric erabutoxin a refined at 1.5 A resolution., Nastopoulos V, Kanellopoulos PN, Tsernoglou D, Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):964-74. PMID:9757111
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