3l4h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3l4h" [edit=sysop:move=sysop])
Line 1: Line 1:
-
{{STRUCTURE_3l4h| PDB=3l4h | SCENE= }}
+
==Helical box domain and second WW domain of the human E3 ubiquitin-protein ligase HECW1==
-
===Helical box domain and second WW domain of the human E3 ubiquitin-protein ligase HECW1===
+
<StructureSection load='3l4h' size='340' side='right' caption='[[3l4h]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==Function==
+
<table><tr><td colspan='2'>[[3l4h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L4H FirstGlance]. <br>
-
[[http://www.uniprot.org/uniprot/HECW1_HUMAN HECW1_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene></td></tr>
-
 
+
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
==About this Structure==
+
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HECW1, KIAA0322, NEDL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-
[[3l4h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L4H OCA].
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l4h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l4h RCSB], [http://www.ebi.ac.uk/pdbsum/3l4h PDBsum]</span></td></tr>
 +
</table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l4/3l4h_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Arrowsmith, C H]]
-
[[Category: Botchkarev, A.]]
+
[[Category: Botchkarev, A]]
-
[[Category: Bountra, C.]]
+
[[Category: Bountra, C]]
-
[[Category: Dhe-Paganon, S.]]
+
[[Category: Dhe-Paganon, S]]
-
[[Category: Edwards, A M.]]
+
[[Category: Edwards, A M]]
-
[[Category: Li, Y.]]
+
[[Category: Li, Y]]
-
[[Category: Qiu, L.]]
+
[[Category: Qiu, L]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Structural genomic]]
-
[[Category: Walker, J R.]]
+
[[Category: Walker, J R]]
-
[[Category: Weigelt, J.]]
+
[[Category: Weigelt, J]]
[[Category: E3 ligase]]
[[Category: E3 ligase]]
[[Category: Helical box domain]]
[[Category: Helical box domain]]
Line 26: Line 39:
[[Category: Protein binding]]
[[Category: Protein binding]]
[[Category: Sgc]]
[[Category: Sgc]]
-
[[Category: Structural genomic]]
 
-
[[Category: Structural genomics consortium]]
 
[[Category: Ubl-conjugation pathway]]
[[Category: Ubl-conjugation pathway]]
[[Category: Ww domain]]
[[Category: Ww domain]]

Revision as of 17:22, 18 December 2014

Helical box domain and second WW domain of the human E3 ubiquitin-protein ligase HECW1

3l4h, resolution 1.80Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools