3m76

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{{STRUCTURE_3m76| PDB=3m76 | SCENE= }}
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==Crystal Structure of Plant SLAC1 homolog TehA==
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===Crystal Structure of Plant SLAC1 homolog TehA===
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<StructureSection load='3m76' size='340' side='right' caption='[[3m76]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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{{ABSTRACT_PUBMED_20981093}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3m76]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M76 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M76 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3m71|3m71]], [[3m72|3m72]], [[3m73|3m73]], [[3m74|3m74]], [[3m75|3m75]], [[3m77|3m77]], [[3m78|3m78]], [[3m7b|3m7b]], [[3m7c|3m7c]], [[3m7e|3m7e]], [[3m7l|3m7l]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HI0511, Rd, tehA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 Haemophilus influenzae])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m76 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m76 RCSB], [http://www.ebi.ac.uk/pdbsum/3m76 PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m7/3m76_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The plant SLAC1 anion channel controls turgor pressure in the aperture-defining guard cells of plant stomata, thereby regulating the exchange of water vapour and photosynthetic gases in response to environmental signals such as drought or high levels of carbon dioxide. Here we determine the crystal structure of a bacterial homologue (Haemophilus influenzae) of SLAC1 at 1.20 A resolution, and use structure-inspired mutagenesis to analyse the conductance properties of SLAC1 channels. SLAC1 is a symmetrical trimer composed from quasi-symmetrical subunits, each having ten transmembrane helices arranged from helical hairpin pairs to form a central five-helix transmembrane pore that is gated by an extremely conserved phenylalanine residue. Conformational features indicate a mechanism for control of gating by kinase activation, and electrostatic features of the pore coupled with electrophysiological characteristics indicate that selectivity among different anions is largely a function of the energetic cost of ion dehydration.
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==About this Structure==
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Homologue structure of the SLAC1 anion channel for closing stomata in leaves.,Chen YH, Hu L, Punta M, Bruni R, Hillerich B, Kloss B, Rost B, Love J, Siegelbaum SA, Hendrickson WA Nature. 2010 Oct 28;467(7319):1074-80. PMID:20981093<ref>PMID:20981093</ref>
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[[3m76]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M76 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:020981093</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
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[[Category: Chen, Y H.]]
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[[Category: Chen, Y H]]
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[[Category: Hendrickson, W A.]]
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[[Category: Hendrickson, W A]]
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[[Category: NYCOMPS, New York Consortium on Membrane Protein Structure.]]
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[[Category: NYCOMPS, New York Consortium on Membrane Protein Structure]]
[[Category: Alpha helical integral membrane protein]]
[[Category: Alpha helical integral membrane protein]]
[[Category: Anion channel]]
[[Category: Anion channel]]
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[[Category: Nycomp]]
[[Category: Nycomp]]
[[Category: Plant slac-1 homolog]]
[[Category: Plant slac-1 homolog]]
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[[Category: Protein structure initiative]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Unknown function]]
[[Category: Unknown function]]

Revision as of 17:23, 18 December 2014

Crystal Structure of Plant SLAC1 homolog TehA

3m76, resolution 1.50Å

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