1qo0
From Proteopedia
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| - | [[Image:1qo0.gif|left|200px]] | + | [[Image:1qo0.gif|left|200px]] |
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| - | '''AMIDE RECEPTOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH THE NEGATIVE REGULATOR AMIR.''' | + | {{Structure |
| + | |PDB= 1qo0 |SIZE=350|CAPTION= <scene name='initialview01'>1qo0</scene>, resolution 2.25Å | ||
| + | |SITE= <scene name='pdbsite=LGA:Butyramide+Binding+Site'>LGA</scene> and <scene name='pdbsite=LGB:Butyramide+Binding+Site'>LGB</scene> | ||
| + | |LIGAND= <scene name='pdbligand=BMD:BUTYRAMIDE'>BMD</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''AMIDE RECEPTOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH THE NEGATIVE REGULATOR AMIR.''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QO0 is a [ | + | 1QO0 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QO0 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure and induction mechanism of AmiC-AmiR: a ligand-regulated transcription antitermination complex., O'Hara BP, Norman RA, Wan PT, Roe SM, Barrett TE, Drew RE, Pearl LH, EMBO J. 1999 Oct 1;18(19):5175-86. PMID:[http:// | + | Crystal structure and induction mechanism of AmiC-AmiR: a ligand-regulated transcription antitermination complex., O'Hara BP, Norman RA, Wan PT, Roe SM, Barrett TE, Drew RE, Pearl LH, EMBO J. 1999 Oct 1;18(19):5175-86. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10508151 10508151] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Pseudomonas aeruginosa]] | [[Category: Pseudomonas aeruginosa]] | ||
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[[Category: receptor]] | [[Category: receptor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:40:19 2008'' |
Revision as of 11:40, 20 March 2008
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| , resolution 2.25Å | |||||||
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| Sites: | and | ||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
AMIDE RECEPTOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH THE NEGATIVE REGULATOR AMIR.
Overview
Inducible expression of the aliphatic amidase operon in Pseudomonas aeruginosa is controlled by an antitermination mechanism which allows production of the full-length transcript only in the presence of small-molecule inducers, such as acetamide. Ligand-regulated antitermination is provided by AmiC, the ligand-sensitive negative regulator, and AmiR, the RNA-binding positive regulator. Under non-inducing or repressing growth conditions, AmiC and AmiR form a complex in which the activity of AmiR is silenced. The crystal structure of the AmiC-AmiR complex identifies AmiR as a new and highly unusual member of the response-regulator family of bacterial signal transduction proteins, regulated by sequestration rather than phosphorylation. Comparison with the structure of free AmiC reveals the subtle mechanism of ligand-induced release of AmiR.
About this Structure
1QO0 is a Protein complex structure of sequences from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.
Reference
Crystal structure and induction mechanism of AmiC-AmiR: a ligand-regulated transcription antitermination complex., O'Hara BP, Norman RA, Wan PT, Roe SM, Barrett TE, Drew RE, Pearl LH, EMBO J. 1999 Oct 1;18(19):5175-86. PMID:10508151
Page seeded by OCA on Thu Mar 20 13:40:19 2008
