3kl8

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{{STRUCTURE_3kl8| PDB=3kl8 | SCENE= }}
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==CaMKIINtide Inhibitor Complex==
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===CaMKIINtide Inhibitor Complex===
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<StructureSection load='3kl8' size='340' side='right' caption='[[3kl8]], [[Resolution|resolution]] 3.37&Aring;' scene=''>
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{{ABSTRACT_PUBMED_20139983}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3kl8]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KL8 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3kk8|3kk8]], [[3kk9|3kk9]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">unc-43, K11E8.1, K11E8.1d ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans]), Camk2n1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kl8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kl8 RCSB], [http://www.ebi.ac.uk/pdbsum/3kl8 PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/3kl8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The dodecameric holoenzyme of calcium-calmodulin-dependent protein kinase II (CaMKII) responds to high-frequency Ca(2+) pulses to become Ca(2+) independent. A simple coincidence-detector model for Ca(2+)-frequency dependency assumes noncooperative activation of kinase domains. We show that activation of CaMKII by Ca(2+)-calmodulin is cooperative, with a Hill coefficient of approximately 3.0, implying sequential kinase-domain activation beyond dimeric units. We present data for a model in which cooperative activation includes the intersubunit 'capture' of regulatory segments. Such a capture interaction is seen in a crystal structure that shows extensive contacts between the regulatory segment of one kinase and the catalytic domain of another. These interactions are mimicked by a natural inhibitor of CaMKII. Our results show that a simple coincidence-detection model cannot be operative and point to the importance of kinetic dissection of the frequency-response mechanism in future experiments.
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==Function==
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Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation.,Chao LH, Pellicena P, Deindl S, Barclay LA, Schulman H, Kuriyan J Nat Struct Mol Biol. 2010 Mar;17(3):264-72. Epub 2010 Feb 7. PMID:20139983<ref>PMID:20139983</ref>
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[[http://www.uniprot.org/uniprot/Q9U6Q0_CAEEL Q9U6Q0_CAEEL]] Role in locomotion and neuronal cell fate specification. Required for the regulation of synaptic density, egg laying, defecation, and meiotic maturation. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor.<ref>PMID:15166144</ref> <ref>PMID:16079277</ref> <ref>PMID:17898212</ref> <ref>PMID:17942636</ref>
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[3kl8]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL8 OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020139983</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Barclay, L A.]]
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[[Category: Barclay, L A]]
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[[Category: Chao, L H.]]
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[[Category: Chao, L H]]
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[[Category: Deindl, S.]]
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[[Category: Deindl, S]]
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[[Category: Kuriyan, J.]]
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[[Category: Kuriyan, J]]
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[[Category: Pellicena, P.]]
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[[Category: Pellicena, P]]
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[[Category: Schulman, H.]]
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[[Category: Schulman, H]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Camkii]]
[[Category: Camkii]]

Revision as of 17:44, 18 December 2014

CaMKIINtide Inhibitor Complex

3kl8, resolution 3.37Å

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