3msv
From Proteopedia
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| - | + | ==The hypoxic regulator of sterol synthesis Nro1 is a nuclear import adaptor== | |
| - | + | <StructureSection load='3msv' size='340' side='right' caption='[[3msv]], [[Resolution|resolution]] 2.18Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3msv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MSV FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPCC4B3.07 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3msv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3msv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3msv RCSB], [http://www.ebi.ac.uk/pdbsum/3msv PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Fission yeast protein Sre1, the homolog of the mammalian sterol regulatory element-binding protein (SREBP), is a hypoxic transcription factor required for sterol homeostasis and low-oxygen growth. Nro1 regulates the stability of the N-terminal transcription factor domain of Sre1 (Sre1N) by inhibiting the action of the prolyl 4-hydroxylase-like Ofd1 in an oxygen-dependent manner. The crystal structure of Nro1 determined at 2.2 A resolution shows an all-alpha-helical fold that can be divided into two domains: a small N-terminal domain, and a larger C-terminal HEAT-repeat domain. Follow-up studies showed that Nro1 defines a new class of nuclear import adaptor that functions both in Ofd1 nuclear localization and in the oxygen-dependent inhibition of Ofd1 to control the hypoxic response. | ||
| - | + | The hypoxic regulator of sterol synthesis nro1 is a nuclear import adaptor.,Yeh TL, Lee CY, Amzel LM, Espenshade PJ, Bianchet MA Structure. 2011 Apr 13;19(4):503-14. PMID:21481773<ref>PMID:21481773</ref> | |
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| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Schizosaccharomyces pombe]] | [[Category: Schizosaccharomyces pombe]] | ||
| - | [[Category: Amzel, L M | + | [[Category: Amzel, L M]] |
| - | [[Category: Bianchet, M A | + | [[Category: Bianchet, M A]] |
| - | [[Category: Yeh, T L | + | [[Category: Yeh, T L]] |
[[Category: Heat repeat]] | [[Category: Heat repeat]] | ||
[[Category: Helix repeat]] | [[Category: Helix repeat]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
Revision as of 17:56, 18 December 2014
The hypoxic regulator of sterol synthesis Nro1 is a nuclear import adaptor
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