1qqs
From Proteopedia
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| - | [[Image:1qqs.gif|left|200px]] | + | [[Image:1qqs.gif|left|200px]] |
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| - | '''NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN HOMODIMER''' | + | {{Structure |
| + | |PDB= 1qqs |SIZE=350|CAPTION= <scene name='initialview01'>1qqs</scene>, resolution 2.40Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NON:METHYL NONANOATE (ESTER)'>NON</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN HOMODIMER''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QQS is a [ | + | 1QQS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQS OCA]. |
==Reference== | ==Reference== | ||
| - | Ligand preference inferred from the structure of neutrophil gelatinase associated lipocalin., Goetz DH, Willie ST, Armen RS, Bratt T, Borregaard N, Strong RK, Biochemistry. 2000 Feb 29;39(8):1935-41. PMID:[http:// | + | Ligand preference inferred from the structure of neutrophil gelatinase associated lipocalin., Goetz DH, Willie ST, Armen RS, Bratt T, Borregaard N, Strong RK, Biochemistry. 2000 Feb 29;39(8):1935-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10684642 10684642] |
[[Category: ]] | [[Category: ]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: signal protein]] | [[Category: signal protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:41:25 2008'' |
Revision as of 11:41, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN HOMODIMER
Overview
Neutrophil gelatinase associated lipocalin (NGAL), a constituent of neutrophil granules, is a member of the lipocalin family of binding proteins. NGAL can also be highly induced in epithelial cells in both inflammatory and neoplastic colorectal disease. NGAL is proposed to mediate inflammatory responses by sequestering neutrophil chemoattractants, particularly N-formylated tripeptides and possibly leukotriene B(4) and platelet activating factor. The crystal structures of NGAL display a typical lipocalin fold, albeit with an unusually large and atypically polar binding site, or calyx. The fold of NGAL is most similar to the epididymal retinoic acid-binding protein, another lipocalin, though the overall architecture of the calyces are very different. The crystal structures also reveal either sulfate ions or an adventitiously copurified fatty acid bound in the binding site. Neither ligand is displaced by added N-formylated tripeptides. The size, shape, and character of the NGAL calyx, as well as the low relative affinity for N-formylated tripeptides, suggest that neither the copurified fatty acid nor any of the proposed ligands are likely to be the preferred ligand of this protein. Comparisons between the crystal structures and the recently reported solution structure of NGAL reveal significant differences, in terms of both the details of the structure and the overall flexibility of the fold.
About this Structure
1QQS is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Ligand preference inferred from the structure of neutrophil gelatinase associated lipocalin., Goetz DH, Willie ST, Armen RS, Bratt T, Borregaard N, Strong RK, Biochemistry. 2000 Feb 29;39(8):1935-41. PMID:10684642 [[Category: ]]
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