3lra

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{{STRUCTURE_3lra| PDB=3lra | SCENE= }}
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==Structural Basis for Assembling a Human Tripartite Complex Dlg1-MPP7-Mals3==
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===Structural Basis for Assembling a Human Tripartite Complex Dlg1-MPP7-Mals3===
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<StructureSection load='3lra' size='340' side='right' caption='[[3lra]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
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{{ABSTRACT_PUBMED_20702775}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3lra]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LRA FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">L27 domains of Dlg1, MPP7 and Mals3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lra OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lra RCSB], [http://www.ebi.ac.uk/pdbsum/3lra PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The establishment of epithelial cell polarity requires the assembly of multiprotein complexes and is crucial during epithelial morphogenesis. Three scaffolding proteins, Dlg1, MPP7, and Mals3, can be assembled to form a complex that functions in the establishment and maintenance of apicobasal polarity in epithelial tissues through their L27 domains. Here we report the crystal structure of a 4-L27-domain complex derived from the human tripartite complex Dlg1-MPP7-Mals3 in combination with paramagnetic relaxation enhancement measurements. The heterotrimer consists of 2 pairs of heterodimeric L27 domains. These 2 dimers are asymmetric due to the large difference between the N- and C-terminal tandem L27 domain of MPP7. Structural analysis combined with biochemical experiments further reveals that the loop alphaA-alphaB and helix alphaB of the C-terminal L27 domain of MPP7 play a critical role in assembling the entire tripartite complex, suggesting a synergistic tandem L27-mediated assembling event.-Yang, X., Xie, X., Chen, L., Zhou, H., Wang, Z., Zhao, W., Tian, R., Zhang, R., Tian, C., Long, J., Shen, Y. Structural basis for tandem L27 domain-mediated polymerization.
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==Function==
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Structural basis for tandem L27 domain-mediated polymerization.,Yang X, Xie X, Chen L, Zhou H, Wang Z, Zhao W, Tian R, Zhang R, Tian C, Long J, Shen Y FASEB J. 2010 Aug 11. PMID:20702775<ref>PMID:20702775</ref>
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[[http://www.uniprot.org/uniprot/DLG1_HUMAN DLG1_HUMAN]] Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.<ref>PMID:10656683</ref> <ref>PMID:12445884</ref> <ref>PMID:14699157</ref> <ref>PMID:15263016</ref> <ref>PMID:19213956</ref> <ref>PMID:20605917</ref>
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[3lra]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRA OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020702775</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Long, J.]]
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[[Category: Long, J]]
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[[Category: Shen, Y.]]
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[[Category: Shen, Y]]
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[[Category: Xie, X.]]
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[[Category: Xie, X]]
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[[Category: Yang, X.]]
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[[Category: Yang, X]]
[[Category: Cell junction]]
[[Category: Cell junction]]
[[Category: Cell membrane]]
[[Category: Cell membrane]]

Revision as of 18:03, 18 December 2014

Structural Basis for Assembling a Human Tripartite Complex Dlg1-MPP7-Mals3

3lra, resolution 2.95Å

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