1qqw

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[[Image:1qqw.gif|left|200px]]<br /><applet load="1qqw" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1qqw.gif|left|200px]]
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caption="1qqw, resolution 2.75&Aring;" />
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'''CRYSTAL STRUCTURE OF HUMAN ERYTHROCYTE CATALASE'''<br />
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{{Structure
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|PDB= 1qqw |SIZE=350|CAPTION= <scene name='initialview01'>1qqw</scene>, resolution 2.75&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN IX CONTAINING FE'>HEM</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6]
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF HUMAN ERYTHROCYTE CATALASE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1QQW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=HEM:'>HEM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1QQW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb57_1.html Catalase]]. Active as [http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQW OCA].
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1QQW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1QQW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb57_1.html Catalase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQW OCA].
==Reference==
==Reference==
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Structure of human erythrocyte catalase., Ko TP, Safo MK, Musayev FN, Di Salvo ML, Wang C, Wu SH, Abraham DJ, Acta Crystallogr D Biol Crystallogr. 2000 Feb;56(Pt 2):241-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10666617 10666617]
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Structure of human erythrocyte catalase., Ko TP, Safo MK, Musayev FN, Di Salvo ML, Wang C, Wu SH, Abraham DJ, Acta Crystallogr D Biol Crystallogr. 2000 Feb;56(Pt 2):241-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10666617 10666617]
[[Category: Catalase]]
[[Category: Catalase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: water]]
[[Category: water]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:42:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:41:28 2008''

Revision as of 11:41, 20 March 2008

Image:1qqw.gif


PDB ID 1qqw

Drag the structure with the mouse to rotate
, resolution 2.75Å
Ligands:
Activity: Catalase, with EC number 1.11.1.6
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF HUMAN ERYTHROCYTE CATALASE


Contents

Overview

Catalase (E.C. 1.11.1.6) was purified from human erythrocytes and crystallized in three different forms: orthorhombic, hexagonal and tetragonal. The structure of the orthorhombic crystal form of human erythrocyte catalase (HEC), with space group P2(1)2(1)2(1) and unit-cell parameters a = 84.9, b = 141.7, c = 232.5 A, was determined and refined with 2.75 A resolution data. Non-crystallographic symmetry restraints were employed and the resulting R value and R(free) were 0.206 and 0.272, respectively. The overall structure and arrangement of HEC molecules in the orthorhombic unit cell were very similar to those of bovine liver catalase (BLC). However, no NADPH was observed in the HEC crystal and a water was bound to the active-site residue His75. Conserved lattice interactions suggested a common growth mechanism for the orthorhombic crystals of HEC and BLC.

Disease

Known disease associated with this structure: Acatalasemia OMIM:[115500]

About this Structure

1QQW is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1QQW with [Catalase]. Full crystallographic information is available from OCA.

Reference

Structure of human erythrocyte catalase., Ko TP, Safo MK, Musayev FN, Di Salvo ML, Wang C, Wu SH, Abraham DJ, Acta Crystallogr D Biol Crystallogr. 2000 Feb;56(Pt 2):241-5. PMID:10666617

Page seeded by OCA on Thu Mar 20 13:41:28 2008

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