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1qrq
From Proteopedia
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| - | [[Image:1qrq.gif|left|200px]] | + | [[Image:1qrq.gif|left|200px]] |
| - | + | ||
| - | '''STRUCTURE OF A VOLTAGE-DEPENDENT K+ CHANNEL BETA SUBUNIT''' | + | {{Structure |
| + | |PDB= 1qrq |SIZE=350|CAPTION= <scene name='initialview01'>1qrq</scene>, resolution 2.80Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NDP:NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE'>NDP</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''STRUCTURE OF A VOLTAGE-DEPENDENT K+ CHANNEL BETA SUBUNIT''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QRQ is a [ | + | 1QRQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QRQ OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of a voltage-dependent K+ channel beta subunit., Gulbis JM, Mann S, MacKinnon R, Cell. 1999 Jun 25;97(7):943-52. PMID:[http:// | + | Structure of a voltage-dependent K+ channel beta subunit., Gulbis JM, Mann S, MacKinnon R, Cell. 1999 Jun 25;97(7):943-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10399921 10399921] |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: voltage-dependent potassium channel]] | [[Category: voltage-dependent potassium channel]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:41:52 2008'' |
Revision as of 11:41, 20 March 2008
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| , resolution 2.80Å | |||||||
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| Ligands: | |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF A VOLTAGE-DEPENDENT K+ CHANNEL BETA SUBUNIT
Overview
The integral membrane subunits of many voltage-dependent potassium channels are associated with an additional protein known as the beta subunit. One function of beta subunits is to modify K+ channel gating. We have determined the structure of the conserved core of mammalian beta subunits by X-ray crystallography at 2.8 A resolution. Like the integral membrane component of K+ channels, beta subunits form a four-fold symmetric structure. Each subunit is an oxidoreductase enzyme complete with a nicotinamide co-factor in its active site. Several structural features of the enzyme active site, including its location with respect to the four-fold axis, imply that it may interact directly or indirectly with the K+ channel's voltage sensor. This structure suggests a mechanism for coupling membrane electrical excitability directly to chemistry of the cell.
About this Structure
1QRQ is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Structure of a voltage-dependent K+ channel beta subunit., Gulbis JM, Mann S, MacKinnon R, Cell. 1999 Jun 25;97(7):943-52. PMID:10399921
Page seeded by OCA on Thu Mar 20 13:41:52 2008
