3org

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{{STRUCTURE_3org| PDB=3org | SCENE= }}
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==Crystal Structure of a eukaryotic CLC transporter==
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===Crystal Structure of a eukaryotic CLC transporter===
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<StructureSection load='3org' size='340' side='right' caption='[[3org]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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{{ABSTRACT_PUBMED_20929736}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3org]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cyanidioschyzon_merolae Cyanidioschyzon merolae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ORG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CLC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=45157 Cyanidioschyzon merolae])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3org FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3org OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3org RCSB], [http://www.ebi.ac.uk/pdbsum/3org PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/or/3org_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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CLC proteins transport chloride (Cl(-)) ions across cell membranes to control the electrical potential of muscle cells, transfer electrolytes across epithelia, and control the pH and electrolyte composition of intracellular organelles. Some members of this protein family are Cl(-) ion channels, whereas others are secondary active transporters that exchange Cl(-) ions and protons (H(+)) with a 2:1 stoichiometry. We have determined the structure of a eukaryotic CLC transporter at 3.5 angstrom resolution. Cytoplasmic cystathionine beta-synthase (CBS) domains are strategically positioned to regulate the ion-transport pathway, and many disease-causing mutations in human CLCs reside on the CBS-transmembrane interface. Comparison with prokaryotic CLC shows that a gating glutamate residue changes conformation and suggests a basis for 2:1 Cl(-)/H(+) exchange and a simple mechanistic connection between CLC channels and transporters.
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==About this Structure==
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Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle.,Feng L, Campbell EB, Hsiung Y, MacKinnon R Science. 2010 Oct 29;330(6004):635-41. Epub 2010 Sep 30. PMID:20929736<ref>PMID:20929736</ref>
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[[3org]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cyanidioschyzon_merolae Cyanidioschyzon merolae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORG OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:020929736</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Cyanidioschyzon merolae]]
[[Category: Cyanidioschyzon merolae]]
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[[Category: Feng, L.]]
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[[Category: Feng, L]]
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[[Category: MacKinnon, R.]]
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[[Category: MacKinnon, R]]
[[Category: Clc]]
[[Category: Clc]]
[[Category: Transport protein]]
[[Category: Transport protein]]
[[Category: Transporter]]
[[Category: Transporter]]

Revision as of 06:32, 19 December 2014

Crystal Structure of a eukaryotic CLC transporter

3org, resolution 3.50Å

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