1qrz
From Proteopedia
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| - | [[Image:1qrz.gif|left|200px]] | + | [[Image:1qrz.gif|left|200px]] |
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| - | '''CATALYTIC DOMAIN OF PLASMINOGEN''' | + | {{Structure |
| + | |PDB= 1qrz |SIZE=350|CAPTION= <scene name='initialview01'>1qrz</scene>, resolution 2.00Å | ||
| + | |SITE= <scene name='pdbsite=ACA:Active+Site+For+Chain+A'>ACA</scene>, <scene name='pdbsite=ACB:Active+Site+For+Chain+B'>ACB</scene>, <scene name='pdbsite=ACC:Active+Site+For+Chain+C'>ACC</scene> and <scene name='pdbsite=ACD:Active+Site+For+Chain+D'>ACD</scene> | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''CATALYTIC DOMAIN OF PLASMINOGEN''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QRZ is a [ | + | 1QRZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QRZ OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the proenzyme domain of plasminogen., Peisach E, Wang J, de los Santos T, Reich E, Ringe D, Biochemistry. 1999 Aug 24;38(34):11180-8. PMID:[http:// | + | Crystal structure of the proenzyme domain of plasminogen., Peisach E, Wang J, de los Santos T, Reich E, Ringe D, Biochemistry. 1999 Aug 24;38(34):11180-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10460175 10460175] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: zymogen]] | [[Category: zymogen]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:41:54 2008'' |
Revision as of 11:41, 20 March 2008
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| , resolution 2.00Å | |||||||
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| Sites: | , , and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CATALYTIC DOMAIN OF PLASMINOGEN
Contents |
Overview
We have solved the X-ray crystal structure of the proenzyme form of the catalytic domain of plasminogen, with the nonessential mutations M585Q, V673M, and M788L, to 2.0 A resolution. The structure presents an inactive protease characterized by Asp740 (chymotrypsinogen 194) hydrogen bonded to His586 (chymotrypsinogen 40), preventing proper formation of the oxyanion hole and S1 specificity pocket. In addition, the catalytic triad residues are misplaced relative to the active conformation adopted by serine proteases in the chymotrypsin family. Finally, a unique form of zymogen inactivation is observed, characterized by a "foot-in-mouth" mechanism in which Trp761 (chymotrypsinogen 215) is folded into the S1 specificity pocket preventing substrate binding.
Disease
Known diseases associated with this structure: Conjunctivitis, ligneous OMIM:[173350], Plasminogen Tochigi disease OMIM:[173350], Plasminogen deficiency, types I and II OMIM:[173350], Thrombophilia, dysplasminogenemic OMIM:[173350]
About this Structure
1QRZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the proenzyme domain of plasminogen., Peisach E, Wang J, de los Santos T, Reich E, Ringe D, Biochemistry. 1999 Aug 24;38(34):11180-8. PMID:10460175
Page seeded by OCA on Thu Mar 20 13:41:54 2008
