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3oix

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{{STRUCTURE_3oix| PDB=3oix | SCENE= }}
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==Crystal structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans==
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===Crystal structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans===
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<StructureSection load='3oix' size='340' side='right' caption='[[3oix]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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{{ABSTRACT_PUBMED_21301083}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3oix]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OIX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OIX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">smu.595 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1309 Streptococcus mutans])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oix OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3oix RCSB], [http://www.ebi.ac.uk/pdbsum/3oix PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oi/3oix_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Streptococcus mutans is one of the pathogenic species involved in dental caries, especially in the initiation and development stages. Here, the crystal structure of SMU.595, a putative dihydroorotate dehydrogenase (DHOD) from S. mutans, is reported at 2.4 A resolution. DHOD is a flavin mononucleotide-containing enzyme which catalyzes the oxidation of L-dihydroorotate to orotate, which is the fourth step and the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. The reductive lysine-methylation procedure was applied in order to improve the diffraction qualities of the crystals. Analysis of the S. mutans DHOD crystal structure shows that this enzyme is a class 1A DHOD and also suggests potential sites that could be exploited for the design of highly specific inhibitors using the structure-based chemotherapeutic design technique.
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==Function==
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Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans.,Liu Y, Gao ZQ, Liu CP, Xu JH, Li LF, Ji CN, Su XD, Dong YH Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Feb 1;67(Pt, 2):182-7. Epub 2011 Jan 21. PMID:21301083<ref>PMID:21301083</ref>
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[[http://www.uniprot.org/uniprot/Q8DVA1_STRMU Q8DVA1_STRMU]] Catalyzes the conversion of dihydroorotate to orotate (By similarity).[HAMAP-Rule:MF_00224]
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[3oix]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OIX OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021301083</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Streptococcus mutans]]
[[Category: Streptococcus mutans]]
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[[Category: Dong, Y H.]]
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[[Category: Dong, Y H]]
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[[Category: Gao, Z Q.]]
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[[Category: Gao, Z Q]]
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[[Category: Liu, C P.]]
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[[Category: Liu, C P]]
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[[Category: Liu, Y.]]
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[[Category: Liu, Y]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Tim barrel]]
[[Category: Tim barrel]]

Revision as of 06:47, 19 December 2014

Crystal structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans

3oix, resolution 2.40Å

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