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3p5n
From Proteopedia
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| - | + | ==Structure and mechanism of the S component of a bacterial ECF transporter== | |
| - | + | <StructureSection load='3p5n' size='340' side='right' caption='[[3p5n]], [[Resolution|resolution]] 3.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3p5n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P5N FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HMPREF0772_2174 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p5n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p5n RCSB], [http://www.ebi.ac.uk/pdbsum/3p5n PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The energy-coupling factor (ECF) transporters, responsible for vitamin uptake in prokaryotes, are a unique family of membrane transporters. Each ECF transporter contains a membrane-embedded, substrate-binding protein (known as the S component), an energy-coupling module that comprises two ATP-binding proteins (known as the A and A' components) and a transmembrane protein (known as the T component). The structure and transport mechanism of the ECF family remain unknown. Here we report the crystal structure of RibU, the S component of the ECF-type riboflavin transporter from Staphylococcus aureus at 3.6-A resolution. RibU contains six transmembrane segments, adopts a previously unreported transporter fold and contains a riboflavin molecule bound to the L1 loop and the periplasmic portion of transmembrane segments 4-6. Structural analysis reveals the essential ligand-binding residues, identifies the putative transport path and, with sequence alignment, uncovers conserved structural features and suggests potential mechanisms of action among the ECF transporters. | ||
| - | + | Structure and mechanism of the S component of a bacterial ECF transporter.,Zhang P, Wang J, Shi Y Nature. 2010 Dec 2;468(7324):717-20. Epub 2010 Oct 24. PMID:20972419<ref>PMID:20972419</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
| - | [[Category: Shi, Y | + | [[Category: Shi, Y]] |
| - | [[Category: Wang, J | + | [[Category: Wang, J]] |
| - | [[Category: Zhang, P | + | [[Category: Zhang, P]] |
[[Category: Alpha-helical bundle]] | [[Category: Alpha-helical bundle]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
[[Category: Transporter]] | [[Category: Transporter]] | ||
Revision as of 06:51, 19 December 2014
Structure and mechanism of the S component of a bacterial ECF transporter
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