3nmx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{STRUCTURE_3nmx| PDB=3nmx | SCENE= }}
+
==Crystal structure of APC complexed with Asef==
-
===Crystal structure of APC complexed with Asef===
+
<StructureSection load='3nmx' size='340' side='right' caption='[[3nmx]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
{{ABSTRACT_PUBMED_021788986}}
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[3nmx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NMX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NMX FirstGlance]. <br>
-
==Function==
+
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nmw|3nmw]], [[3nmz|3nmz]]</td></tr>
-
[[http://www.uniprot.org/uniprot/ARHG4_HUMAN ARHG4_HUMAN]] Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.<ref>PMID:10947987</ref><ref>PMID:12598901</ref><ref>PMID:17145773</ref><ref>PMID:17599059</ref><ref>PMID:19893577</ref>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nmx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nmx RCSB], [http://www.ebi.ac.uk/pdbsum/3nmx PDBsum]</span></td></tr>
-
 
+
</table>
-
==About this Structure==
+
__TOC__
-
[[3nmx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NMX OCA].
+
</StructureSection>
-
 
+
-
==Reference==
+
-
<references group="xtra"/><references/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Chen, L.]]
+
[[Category: Chen, L]]
-
[[Category: Gao, L.]]
+
[[Category: Gao, L]]
-
[[Category: Lin, K.]]
+
[[Category: Lin, K]]
-
[[Category: Wu, G.]]
+
[[Category: Wu, G]]
-
[[Category: Zhang, Z.]]
+
[[Category: Zhang, Z]]
[[Category: Cell adhesion-cell cycle complex]]
[[Category: Cell adhesion-cell cycle complex]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]

Revision as of 07:07, 19 December 2014

Crystal structure of APC complexed with Asef

3nmx, resolution 2.30Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3nmx"
Personal tools