3nth
From Proteopedia
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| - | + | ==Crystal structure of Tudor and Aubergine [R13(me2s)] complex== | |
| - | + | <StructureSection load='3nth' size='340' side='right' caption='[[3nth]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3nth]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NTH FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2MR:N3,+N4-DIMETHYLARGININE'>2MR</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nti|3nti]], [[3ntk|3ntk]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tud ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nth OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nth RCSB], [http://www.ebi.ac.uk/pdbsum/3nth PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/3nth_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Piwi proteins are modified by symmetric dimethylation of arginine (sDMA), and the methylarginine-dependent interaction with Tudor domain proteins is critical for their functions in germline development. Cocrystal structures of an extended Tudor domain (eTud) of Drosophila Tudor with methylated peptides of Aubergine, a Piwi family protein, reveal that sDMA is recognized by an asparagine-gated aromatic cage. Furthermore, the unexpected Tudor-SN/p100 fold of eTud is important for sensing the position of sDMA. The structural information provides mechanistic insights into sDMA-dependent Piwi-Tudor interaction, and the recognition of sDMA by Tudor domains in general. | ||
| - | + | Structural basis for methylarginine-dependent recognition of Aubergine by Tudor.,Liu H, Wang JY, Huang Y, Li Z, Gong W, Lehmann R, Xu RM Genes Dev. 2010 Sep 1;24(17):1876-81. Epub 2010 Aug 16. PMID:20713507<ref>PMID:20713507</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
| - | [[Category: Gong, W M | + | [[Category: Gong, W M]] |
| - | [[Category: Huang, Y | + | [[Category: Huang, Y]] |
| - | [[Category: Li, Z Z | + | [[Category: Li, Z Z]] |
| - | [[Category: Liu, H P | + | [[Category: Liu, H P]] |
| - | [[Category: Xu, R M | + | [[Category: Xu, R M]] |
[[Category: Germ cell formation]] | [[Category: Germ cell formation]] | ||
[[Category: Ob-fold]] | [[Category: Ob-fold]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Tudor domain]] | [[Category: Tudor domain]] | ||
Revision as of 07:07, 19 December 2014
Crystal structure of Tudor and Aubergine [R13(me2s)] complex
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