3o47

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{{STRUCTURE_3o47| PDB=3o47 | SCENE= }}
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==Crystal structure of ARFGAP1-ARF1 fusion protein==
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===Crystal structure of ARFGAP1-ARF1 fusion protein===
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<StructureSection load='3o47' size='340' side='right' caption='[[3o47]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3o47]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O47 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O47 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/ARFG1_HUMAN ARFG1_HUMAN]] GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity).
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARFGAP1, ARF1GAP, ARF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o47 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o47 RCSB], [http://www.ebi.ac.uk/pdbsum/3o47 PDBsum]</span></td></tr>
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[[3o47]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O47 OCA].
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</table>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev, A]]
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[[Category: Bountra, C.]]
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[[Category: Bountra, C]]
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[[Category: Crombet, L.]]
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[[Category: Crombet, L]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards, A M]]
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[[Category: Guan, X.]]
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[[Category: Guan, X]]
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[[Category: Nedyalkova, L.]]
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[[Category: Nedyalkova, L]]
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[[Category: Park, H.]]
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[[Category: Park, H]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Structural genomic]]
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[[Category: Tempel, W.]]
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[[Category: Tempel, W]]
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[[Category: Tong, Y.]]
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[[Category: Tong, Y]]
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[[Category: Wang, H.]]
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[[Category: Wang, H]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt, J]]
[[Category: Chimera protein]]
[[Category: Chimera protein]]
[[Category: Fusion protein]]
[[Category: Fusion protein]]
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[[Category: Hydrolase activator]]
[[Category: Hydrolase activator]]
[[Category: Sgc]]
[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
 

Revision as of 07:10, 19 December 2014

Crystal structure of ARFGAP1-ARF1 fusion protein

3o47, resolution 2.80Å

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