3nrk
From Proteopedia
(Difference between revisions)
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| - | + | ==The crystal structure of the leptospiral hypothetical protein LIC12922== | |
| - | ===The crystal structure of the | + | <StructureSection load='3nrk' size='340' side='right' caption='[[3nrk]], [[Resolution|resolution]] 3.10Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3nrk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leptospira_interrogans_serovar_copenhageni Leptospira interrogans serovar copenhageni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NRK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NRK FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LIC12922, LIC_12922 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44275 Leptospira interrogans serovar Copenhageni])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nrk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nrk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nrk RCSB], [http://www.ebi.ac.uk/pdbsum/3nrk PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Leptospirosis is a world spread zoonosis caused by members of the genus Leptospira. Although leptospires were identified as the causal agent of leptospirosis almost 100years ago, little is known about their biology, which hinders the development of new treatment and prevention strategies. One of the several aspects of the leptospiral biology not yet elucidated is the process by which outer membrane proteins (OMPs) traverse the periplasm and are inserted into the outer membrane. The crystal structure determination of the conserved hypothetical protein LIC12922 from Leptospira interrogans revealed a two domain protein homologous to the Escherichia coli periplasmic chaperone SurA. The LIC12922 NC-domain is structurally related to the chaperone modules of E. coli SurA and trigger factor, whereas the parvulin domain is devoid of peptidyl prolyl cis-trans isomerase activity. Phylogenetic analyses suggest a relationship between LIC12922 and the chaperones PrsA, PpiD and SurA. Based on our structural and evolutionary analyses, we postulate that LIC12922 is a periplasmic chaperone involved in OMPs biogenesis in Leptospira spp. Since LIC12922 homologs were identified in all spirochetal genomes sequenced to date, this assumption may have implications for the OMPs biogenesis studies not only in leptospires but in the entire Phylum Spirochaetes. | ||
| - | + | The crystal structure of the leptospiral hypothetical protein LIC12922 reveals homology with the periplasmic chaperone SurA.,Giuseppe PO, Atzingen MV, Nascimento AL, Zanchin NI, Guimaraes BG J Struct Biol. 2010 Oct 21. PMID:20970503<ref>PMID:20970503</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Leptospira interrogans serovar copenhageni]] | [[Category: Leptospira interrogans serovar copenhageni]] | ||
| - | [[Category: Atzingen, M V | + | [[Category: Atzingen, M V]] |
| - | [[Category: Giuseppe, P O | + | [[Category: Giuseppe, P O]] |
| - | [[Category: Guimaraes, B G | + | [[Category: Guimaraes, B G]] |
| - | [[Category: Nascimento, A L.T O | + | [[Category: Nascimento, A L.T O]] |
| - | [[Category: Zanchin, N I.T | + | [[Category: Zanchin, N I.T]] |
[[Category: Nc domain]] | [[Category: Nc domain]] | ||
[[Category: Parvulin domain]] | [[Category: Parvulin domain]] | ||
Revision as of 07:18, 19 December 2014
The crystal structure of the leptospiral hypothetical protein LIC12922
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