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3p5t

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{{STRUCTURE_3p5t| PDB=3p5t | SCENE= }}
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==CFIm25-CFIm68 complex==
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===CFIm25-CFIm68 complex===
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<StructureSection load='3p5t' size='340' side='right' caption='[[3p5t]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3p5t]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P5T FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/CPSF5_HUMAN CPSF5_HUMAN]] Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:20479262</ref> <ref>PMID:21295486</ref> [[http://www.uniprot.org/uniprot/CPSF6_HUMAN CPSF6_HUMAN]] Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:21295486</ref>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3p6y|3p6y]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUDT21, CFIM25, CPSF25, CPSF5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), CPSF6, CFIM68 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p5t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p5t RCSB], [http://www.ebi.ac.uk/pdbsum/3p5t PDBsum]</span></td></tr>
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[[3p5t]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5T OCA].
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</table>
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__TOC__
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==Reference==
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</StructureSection>
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Gao, Y.]]
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[[Category: Gao, Y]]
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[[Category: Ge, H.]]
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[[Category: Ge, H]]
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[[Category: Li, H.]]
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[[Category: Li, H]]
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[[Category: Li, X.]]
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[[Category: Li, X]]
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[[Category: Niu, L.]]
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[[Category: Niu, L]]
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[[Category: Shi, H.]]
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[[Category: Shi, H]]
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[[Category: Teng, M.]]
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[[Category: Teng, M]]
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[[Category: Tong, S.]]
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[[Category: Tong, S]]
[[Category: Nuclear]]
[[Category: Nuclear]]
[[Category: Rna]]
[[Category: Rna]]
[[Category: Rna binding protein]]
[[Category: Rna binding protein]]
[[Category: Rrm domain]]
[[Category: Rrm domain]]

Revision as of 07:20, 19 December 2014

CFIm25-CFIm68 complex

3p5t, resolution 2.70Å

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