1qxo

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[[Image:1qxo.jpg|left|200px]]<br /><applet load="1qxo" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1qxo.jpg|left|200px]]
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caption="1qxo, resolution 2.0&Aring;" />
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'''Crystal structure of Chorismate synthase complexed with oxidized FMN and EPSP'''<br />
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{{Structure
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|PDB= 1qxo |SIZE=350|CAPTION= <scene name='initialview01'>1qxo</scene>, resolution 2.0&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NCO:COBALT+HEXAMMINE+ION'>NCO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene> and <scene name='pdbligand=EPS:5-[(1-CARBOXYVINYL)OXY]-4-HYDROXY-3-(PHOSPHONOOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID'>EPS</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Chorismate_synthase Chorismate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.5 4.2.3.5]
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|GENE= AROC, SP1374 OR SPR1232 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])
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}}
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'''Crystal structure of Chorismate synthase complexed with oxidized FMN and EPSP'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1QXO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae] with <scene name='pdbligand=NCO:'>NCO</scene>, <scene name='pdbligand=EDO:'>EDO</scene>, <scene name='pdbligand=FMN:'>FMN</scene> and <scene name='pdbligand=EPS:'>EPS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Chorismate_synthase Chorismate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.5 4.2.3.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QXO OCA].
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1QXO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QXO OCA].
==Reference==
==Reference==
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The structure of chorismate synthase reveals a novel flavin binding site fundamental to a unique chemical reaction., Maclean J, Ali S, Structure. 2003 Dec;11(12):1499-511. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14656434 14656434]
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The structure of chorismate synthase reveals a novel flavin binding site fundamental to a unique chemical reaction., Maclean J, Ali S, Structure. 2003 Dec;11(12):1499-511. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14656434 14656434]
[[Category: Chorismate synthase]]
[[Category: Chorismate synthase]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: shikimate]]
[[Category: shikimate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:44:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:44:16 2008''

Revision as of 11:44, 20 March 2008

Image:1qxo.jpg


PDB ID 1qxo

Drag the structure with the mouse to rotate
, resolution 2.0Å
Ligands: , , and
Gene: AROC, SP1374 OR SPR1232 (Streptococcus pneumoniae)
Activity: Chorismate synthase, with EC number 4.2.3.5
Coordinates: save as pdb, mmCIF, xml



Crystal structure of Chorismate synthase complexed with oxidized FMN and EPSP


Overview

The crystal structure of chorismate synthase (CS) from Streptococcus pneumoniae has been solved to 2.0 A resolution in the presence of flavin mononucleotide (FMN) and the substrate 5-enolpyruvyl-3-shikimate phosphate (EPSP). CS catalyses the final step of the shikimate pathway and is a potential therapeutic target for the rational design of novel antibacterials, antifungals, antiprotozoals, and herbicides. CS is a tetramer with the monomer possessing a novel beta-alpha-beta fold. The interactions between the enzyme, cofactor, and substrate reveal the structural reasons underlying the unique catalytic mechanism and identify the amino acids involved. This structure provides the essential initial information necessary for the generation of novel anti-infective compounds by a structure-guided medicinal chemistry approach.

About this Structure

1QXO is a Single protein structure of sequence from Streptococcus pneumoniae. Full crystallographic information is available from OCA.

Reference

The structure of chorismate synthase reveals a novel flavin binding site fundamental to a unique chemical reaction., Maclean J, Ali S, Structure. 2003 Dec;11(12):1499-511. PMID:14656434

Page seeded by OCA on Thu Mar 20 13:44:16 2008

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