1r09

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[[Image:1r09.jpg|left|200px]]<br /><applet load="1r09" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1r09.jpg|left|200px]]
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caption="1r09, resolution 2.9&Aring;" />
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'''HUMAN RHINOVIRUS 14 COMPLEXED WITH ANTIVIRAL COMPOUND R 61837'''<br />
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{{Structure
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|PDB= 1r09 |SIZE=350|CAPTION= <scene name='initialview01'>1r09</scene>, resolution 2.9&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=JEN:3-METHOXY-6-[4-(3-METHYLPHENYL)-1-PIPERAZINYL]PYRIDAZINE'>JEN</scene> and <scene name='pdbligand=DMS:DIMETHYL SULFOXIDE'>DMS</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''HUMAN RHINOVIRUS 14 COMPLEXED WITH ANTIVIRAL COMPOUND R 61837'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1R09 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_rhinovirus_10 Human rhinovirus 10] with <scene name='pdbligand=JEN:'>JEN</scene> and <scene name='pdbligand=DMS:'>DMS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R09 OCA].
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1R09 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_rhinovirus_10 Human rhinovirus 10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R09 OCA].
==Reference==
==Reference==
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Human rhinovirus 14 complexed with antiviral compound R 61837., Chapman MS, Minor I, Rossmann MG, Diana GD, Andries K, J Mol Biol. 1991 Feb 5;217(3):455-63. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1847215 1847215]
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Human rhinovirus 14 complexed with antiviral compound R 61837., Chapman MS, Minor I, Rossmann MG, Diana GD, Andries K, J Mol Biol. 1991 Feb 5;217(3):455-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1847215 1847215]
[[Category: Human rhinovirus 10]]
[[Category: Human rhinovirus 10]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: rhinovirus coat protein]]
[[Category: rhinovirus coat protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:45:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:45:07 2008''

Revision as of 11:45, 20 March 2008

Image:1r09.jpg


PDB ID 1r09

Drag the structure with the mouse to rotate
, resolution 2.9Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



HUMAN RHINOVIRUS 14 COMPLEXED WITH ANTIVIRAL COMPOUND R 61837


Overview

The binding of the antirhinoviral agent R 61837 to human rhinovirus 14 has been examined by X-ray crystallographic methods. The compound R 61837 binds in the same pocket (underneath the canyon floor) as the "WIN" antirhinoviral agents. It does not penetrate as far into the pocket but causes similar conformational changes in the virus capsid. The movement of residues 1217 to 1221 of viral protein 1 (in the "FMDV loop") is more pronounced for R 61837 than for WIN compounds. Although both R 61837 and WIN antiviral agents partially fill the same hydrophobic pocket, atomic binding interactions differ, showing that considerable diversity in the nature of antiviral agents is possible.

About this Structure

1R09 is a Protein complex structure of sequences from Human rhinovirus 10. Full crystallographic information is available from OCA.

Reference

Human rhinovirus 14 complexed with antiviral compound R 61837., Chapman MS, Minor I, Rossmann MG, Diana GD, Andries K, J Mol Biol. 1991 Feb 5;217(3):455-63. PMID:1847215

Page seeded by OCA on Thu Mar 20 13:45:07 2008

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