3pz8

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{{STRUCTURE_3pz8| PDB=3pz8 | SCENE= }}
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==Crystal structure of Dvl1-DIX(Y17D) mutant==
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===Crystal structure of Dvl1-DIX(Y17D) mutant===
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<StructureSection load='3pz8' size='340' side='right' caption='[[3pz8]], [[Resolution|resolution]] 2.87&Aring;' scene=''>
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{{ABSTRACT_PUBMED_021189423}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3pz8]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PZ8 FirstGlance]. <br>
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==Function==
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Dvl1, Dvl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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[[http://www.uniprot.org/uniprot/DVL1_MOUSE DVL1_MOUSE]] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).<ref>PMID:12165471</ref> <ref>PMID:15353129</ref> <ref>PMID:11101902</ref> <ref>PMID:19637179</ref>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pz8 RCSB], [http://www.ebi.ac.uk/pdbsum/3pz8 PDBsum]</span></td></tr>
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</table>
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==About this Structure==
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__TOC__
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[[3pz8]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ8 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:021189423</ref><references group="xtra"/><references/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Chen, L.]]
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[[Category: Chen, L]]
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[[Category: Dan, Q J.]]
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[[Category: Dan, Q J]]
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[[Category: Liu, Y T.]]
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[[Category: Liu, Y T]]
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[[Category: Wu, J W.]]
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[[Category: Wu, J W]]
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[[Category: Zhang, Y Y.]]
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[[Category: Zhang, Y Y]]
[[Category: Dix domain]]
[[Category: Dix domain]]
[[Category: Oligomerization]]
[[Category: Oligomerization]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]

Revision as of 10:54, 19 December 2014

Crystal structure of Dvl1-DIX(Y17D) mutant

3pz8, resolution 2.87Å

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