3qpk
From Proteopedia
(Difference between revisions)
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| - | + | ==Probing oxygen channels in Melanocarpus albomyces laccase== | |
| - | === | + | <StructureSection load='3qpk' size='340' side='right' caption='[[3qpk]], [[Resolution|resolution]] 1.90Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3qpk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Melanocarpus_albomyces Melanocarpus albomyces]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QPK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QPK FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XE:XENON'>XE</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gw0|1gw0]], [[2ih8|2ih8]], [[2ih9|2ih9]], [[2q9o|2q9o]], [[3dkh|3dkh]], [[3fu7|3fu7]], [[3fu8|3fu8]], [[3fu9|3fu9]], [[3pps|3pps]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LAC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=204285 Melanocarpus albomyces])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Laccase Laccase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qpk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qpk RCSB], [http://www.ebi.ac.uk/pdbsum/3qpk PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Laccases catalyze the oxidation of phenolic substrates and the concominant reduction of dioxygen to water. We used xenon as an oxygen probe in search of routes for the entry of dioxygen into the catalytic center. Two xenon-pressurized crystal structures of recombinant Melanocarpus albomyces laccase were determined, showing three hydrophobic Xe-binding sites located in domain C. The analysis of hydrophobic cavities in other laccase structures further suggested the preference of domain C for binding of hydrophobic species such as dioxygen, thus suggesting that the hydrophobic core of domain C could function as a channel through which dioxygen can enter the trinuclear copper center. | ||
| - | + | Probing the Dioxygen Route in Melanocarpus albomyces Laccase with Pressurized Xenon Gas.,Kallio JP, Rouvinen J, Kruus K, Hakulinen N Biochemistry. 2011 May 5. PMID:21524088<ref>PMID:21524088</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Laccase]] | [[Category: Laccase]] | ||
[[Category: Melanocarpus albomyces]] | [[Category: Melanocarpus albomyces]] | ||
| - | [[Category: Hakulinen, N | + | [[Category: Hakulinen, N]] |
| - | [[Category: Kallio, J P | + | [[Category: Kallio, J P]] |
| - | [[Category: Rouvinen, J | + | [[Category: Rouvinen, J]] |
[[Category: Cu binding]] | [[Category: Cu binding]] | ||
| - | [[Category: Laccase]] | ||
[[Category: Multicopper oxidase]] | [[Category: Multicopper oxidase]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Xe binding]] | [[Category: Xe binding]] | ||
Revision as of 11:03, 19 December 2014
Probing oxygen channels in Melanocarpus albomyces laccase
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