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3qd7

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{{STRUCTURE_3qd7| PDB=3qd7 | SCENE= }}
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==Crystal structure of YdaL, a stand-alone small MutS-related protein from Escherichia coli==
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===Crystal structure of YdaL, a stand-alone small MutS-related protein from Escherichia coli===
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<StructureSection load='3qd7' size='340' side='right' caption='[[3qd7]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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{{ABSTRACT_PUBMED_21276852}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qd7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QD7 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ydaL, b1340, JW1334 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qd7 RCSB], [http://www.ebi.ac.uk/pdbsum/3qd7 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Sequence homologs of the small MutS-related (Smr) domain, the C-terminal endonuclease domain of MutS2, also exist as stand-alone proteins. In this study, we report the crystal structure of a proteolyzed fragment of YdaL (YdaL-), a stand-alone Smr protein from Escherichia coli. In this structure, residues 86-170 assemble into a classical Smr core domain and are embraced by an N-terminal extension (residues 40-85) with an alpha/beta/alpha fold. Sequence alignment indicates that the N-terminal extension is conserved among a number of stand-alone Smr proteins, suggesting structural diversity among Smr domains. We also discovered that the DNA binding affinity and endonuclease activity of the truncated YdaL- protein were slightly lower than those of full-length YdaL-, suggesting that residues 1-38 may be involved in DNA binding.
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==Function==
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Crystal structure of YdaL, a stand-alone small MutS-related protein from Escherichia coli.,Gui WJ, Qu QH, Chen YY, Wang M, Zhang XE, Bi LJ, Jiang T J Struct Biol. 2011 May;174(2):282-9. Epub 2011 Jan 27. PMID:21276852<ref>PMID:21276852</ref>
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[[http://www.uniprot.org/uniprot/SMRA_ECOLI SMRA_ECOLI]] Has DNA endonuclease activity. Binds DNA.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[3qd7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QD7 OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021276852</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Bi, L J.]]
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[[Category: Bi, L J]]
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[[Category: Chen, Y Y.]]
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[[Category: Chen, Y Y]]
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[[Category: Gui, W J.]]
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[[Category: Gui, W J]]
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[[Category: Jiang, T.]]
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[[Category: Jiang, T]]
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[[Category: Qu, Q H.]]
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[[Category: Qu, Q H]]
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[[Category: Wang, M.]]
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[[Category: Wang, M]]
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[[Category: Zhang, X E.]]
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[[Category: Zhang, X E]]
[[Category: Alpha/beta/alpha fold]]
[[Category: Alpha/beta/alpha fold]]
[[Category: Endonuclease]]
[[Category: Endonuclease]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Revision as of 11:03, 19 December 2014

Crystal structure of YdaL, a stand-alone small MutS-related protein from Escherichia coli

3qd7, resolution 2.30Å

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