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3qve

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{{STRUCTURE_3qve| PDB=3qve | SCENE= }}
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==Crystal structure of human HMG box-containing protein 1, HBP1==
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===Crystal structure of human HMG box-containing protein 1, HBP1===
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<StructureSection load='3qve' size='340' side='right' caption='[[3qve]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3qve]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QVE FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/HBP1_HUMAN HBP1_HUMAN]] Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.<ref>PMID:10958660</ref> <ref>PMID:10562551</ref> <ref>PMID:11500377</ref>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qve OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qve RCSB], [http://www.ebi.ac.uk/pdbsum/3qve PDBsum]</span></td></tr>
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[[3qve]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVE OCA].
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</table>
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__TOC__
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==Reference==
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</StructureSection>
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C.]]
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[[Category: Bountra, C]]
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[[Category: Chaikuad, A.]]
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[[Category: Chaikuad, A]]
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[[Category: Cocking, R.]]
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[[Category: Cocking, R]]
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[[Category: Consortium, Structural Genomics.]]
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[[Category: Structural genomic]]
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[[Category: Delft, F von.]]
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[[Category: Delft, F von]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards, A M]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Filippakopoulos, P]]
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[[Category: Krojer, T.]]
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[[Category: Krojer, T]]
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[[Category: Krysztofinska, E.]]
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[[Category: Krysztofinska, E]]
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[[Category: Oppermann, U.]]
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[[Category: Oppermann, U]]
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[[Category: Ugochukwu, E.]]
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[[Category: Ugochukwu, E]]
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[[Category: Vollmar, M.]]
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[[Category: Vollmar, M]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt, J]]
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[[Category: Yue, W W.]]
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[[Category: Yue, W W]]
[[Category: Axh domain]]
[[Category: Axh domain]]
[[Category: Hbp1]]
[[Category: Hbp1]]
[[Category: Hmg box transcription factor 1]]
[[Category: Hmg box transcription factor 1]]
[[Category: Sgc]]
[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
 
[[Category: Transcription]]
[[Category: Transcription]]

Revision as of 11:07, 19 December 2014

Crystal structure of human HMG box-containing protein 1, HBP1

3qve, resolution 2.04Å

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