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1r5i

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[[Image:1r5i.gif|left|200px]]<br /><applet load="1r5i" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1r5i.gif|left|200px]]
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caption="1r5i, resolution 2.60&Aring;" />
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'''Crystal structure of the MAM-MHC complex'''<br />
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{{Structure
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|PDB= 1r5i |SIZE=350|CAPTION= <scene name='initialview01'>1r5i</scene>, resolution 2.60&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE ION'>PO4</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal structure of the MAM-MHC complex'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1R5I is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mycoplasma_arthritidis Mycoplasma arthritidis] with <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R5I OCA].
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1R5I is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mycoplasma_arthritidis Mycoplasma arthritidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R5I OCA].
==Reference==
==Reference==
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Crystal structure of Mycoplasma arthritidis mitogen complexed with HLA-DR1 reveals a novel superantigen fold and a dimerized superantigen-MHC complex., Zhao Y, Li Z, Drozd SJ, Guo Y, Mourad W, Li H, Structure. 2004 Feb;12(2):277-88. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14962388 14962388]
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Crystal structure of Mycoplasma arthritidis mitogen complexed with HLA-DR1 reveals a novel superantigen fold and a dimerized superantigen-MHC complex., Zhao Y, Li Z, Drozd SJ, Guo Y, Mourad W, Li H, Structure. 2004 Feb;12(2):277-88. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14962388 14962388]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mycoplasma arthritidis]]
[[Category: Mycoplasma arthritidis]]
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[[Category: superantigen]]
[[Category: superantigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:47:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:47:06 2008''

Revision as of 11:47, 20 March 2008

Image:1r5i.gif


PDB ID 1r5i

Drag the structure with the mouse to rotate
, resolution 2.60Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



Crystal structure of the MAM-MHC complex


Overview

Mycoplasma arthritidis-derived mitogen (MAM) is a superantigen that can activate large fractions of T cells bearing particular TCR Vbeta elements. Here we report the crystal structure of MAM complexed with a major histocompatibility complex (MHC) antigen, HLA-DR1, loaded with haemagglutinin peptide 306-318 (HA). The structure reveals that MAM has a novel fold composed of two alpha-helical domains. This fold is entirely different from that of the pyrogenic superantigens, consisting of a beta-grasped motif and a beta barrel. In the complex, the N-terminal domain of MAM binds orthogonally to the MHC alpha1 domain and the bound HA peptide, and to a lesser extent to the MHC beta1 domain. Two MAM molecules form an asymmetric dimer and cross-link two MHC antigens to form a plausible, dimerized MAM-MHC complex. These data provide the first crystallographic evidence that superantigens can dimerize MHC molecules. Based on our structure, a model of the TCR2MAM2MHC2 complex is proposed.

About this Structure

1R5I is a Protein complex structure of sequences from Homo sapiens and Mycoplasma arthritidis. Full crystallographic information is available from OCA.

Reference

Crystal structure of Mycoplasma arthritidis mitogen complexed with HLA-DR1 reveals a novel superantigen fold and a dimerized superantigen-MHC complex., Zhao Y, Li Z, Drozd SJ, Guo Y, Mourad W, Li H, Structure. 2004 Feb;12(2):277-88. PMID:14962388

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