3pkj

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{{STRUCTURE_3pkj| PDB=3pkj | SCENE= }}
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==Human SIRT6 crystal structure in complex with 2'-N-Acetyl ADP ribose==
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===Human SIRT6 crystal structure in complex with 2'-N-Acetyl ADP ribose===
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<StructureSection load='3pkj' size='340' side='right' caption='[[3pkj]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
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{{ABSTRACT_PUBMED_021362626}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3pkj]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PKJ FirstGlance]. <br>
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==Function==
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2N:[(2R,3S,4R,5R)-4-(ACETYLAMINO)-3,5-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>A2N</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[http://www.uniprot.org/uniprot/SIRT6_HUMAN SIRT6_HUMAN]] NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.<ref>PMID:18337721</ref> <ref>PMID:19135889</ref> <ref>PMID:19625767</ref> <ref>PMID:20829486</ref> <ref>PMID:21362626</ref>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3k35|3k35]], [[3pki|3pki]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SIRT6, SIR2L6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pkj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pkj RCSB], [http://www.ebi.ac.uk/pdbsum/3pkj PDBsum]</span></td></tr>
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[[3pkj]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKJ OCA].
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</table>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:021362626</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C.]]
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[[Category: Bountra, C]]
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[[Category: Dong, A.]]
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[[Category: Dong, A]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards, A M]]
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[[Category: Loppnau, P.]]
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[[Category: Loppnau, P]]
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[[Category: Min, J.]]
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[[Category: Min, J]]
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[[Category: Pan, P W.]]
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[[Category: Pan, P W]]
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[[Category: Qiu, W.]]
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[[Category: Qiu, W]]
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[[Category: Ravichandran, M.]]
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[[Category: Ravichandran, M]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Structural genomic]]
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[[Category: Walker, J R.]]
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[[Category: Walker, J R]]
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[[Category: Wang, J.]]
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[[Category: Wang, J]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt, J]]
[[Category: 2'-n-acetyl adp ribose]]
[[Category: 2'-n-acetyl adp ribose]]
[[Category: Adp-ribosylation]]
[[Category: Adp-ribosylation]]
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[[Category: Rossmann fold]]
[[Category: Rossmann fold]]
[[Category: Sgc]]
[[Category: Sgc]]
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[[Category: Structural genomic]]
 
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[[Category: Structural genomics consortium]]
 
[[Category: Zn-binding domain]]
[[Category: Zn-binding domain]]

Revision as of 11:11, 19 December 2014

Human SIRT6 crystal structure in complex with 2'-N-Acetyl ADP ribose

3pkj, resolution 2.12Å

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