1r6g

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[[Image:1r6g.gif|left|200px]]<br /><applet load="1r6g" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1r6g.gif|left|200px]]
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caption="1r6g, resolution 3.00&Aring;" />
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'''Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound'''<br />
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{{Structure
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|PDB= 1r6g |SIZE=350|CAPTION= <scene name='initialview01'>1r6g</scene>, resolution 3.00&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=442:2-[3,5-DIBROMO-4-(4-HYDROXY-3-{HYDROXY[(2-PHENYLETHYL)AMINO]METHYL}PHENOXY)PHENYL]ETHANE-1,1-DIOL'>442</scene>
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|ACTIVITY=
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|GENE= THRB, NR1A2, ERBA2, THR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1R6G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=442:'>442</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6G OCA].
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1R6G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6G OCA].
==Reference==
==Reference==
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Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta., Hangeland JJ, Doweyko AM, Dejneka T, Friends TJ, Devasthale P, Mellstrom K, Sandberg J, Grynfarb M, Sack JS, Einspahr H, Farnegardh M, Husman B, Ljunggren J, Koehler K, Sheppard C, Malm J, Ryono DE, Bioorg Med Chem Lett. 2004 Jul 5;14(13):3549-53. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15177471 15177471]
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Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta., Hangeland JJ, Doweyko AM, Dejneka T, Friends TJ, Devasthale P, Mellstrom K, Sandberg J, Grynfarb M, Sack JS, Einspahr H, Farnegardh M, Husman B, Ljunggren J, Koehler K, Sheppard C, Malm J, Ryono DE, Bioorg Med Chem Lett. 2004 Jul 5;14(13):3549-53. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15177471 15177471]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: alpha helical]]
[[Category: alpha helical]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:47:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:47:28 2008''

Revision as of 11:47, 20 March 2008

Image:1r6g.gif


PDB ID 1r6g

Drag the structure with the mouse to rotate
, resolution 3.00Å
Ligands:
Gene: THRB, NR1A2, ERBA2, THR1 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound


Contents

Overview

A set of thyromimetics having improved selectivity for TR-beta1 were prepared by replacing the 3'-isopropyl group of 2 and 3 with substituents having increased steric bulk. From this limited SAR study, the most potent and selective compounds identified were derived from 2 and contained a 3'-phenyl moiety bearing small hydrophobic groups meta to the biphenyl link. X-ray crystal data of 15c complexed with TR-beta1 LBD shows methionine 442 to be displaced by the bulky R3' phenyl ethyl amide side chain. Movement of this amino acid side chain provides an expanded pocket for the bulky side chain while the ligand-receptor complex retains full agonist activity.

Disease

Known diseases associated with this structure: Thyroid hormone resistance OMIM:[190160], Thyroid hormone resistance, autosomal recessive OMIM:[190160]

About this Structure

1R6G is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta., Hangeland JJ, Doweyko AM, Dejneka T, Friends TJ, Devasthale P, Mellstrom K, Sandberg J, Grynfarb M, Sack JS, Einspahr H, Farnegardh M, Husman B, Ljunggren J, Koehler K, Sheppard C, Malm J, Ryono DE, Bioorg Med Chem Lett. 2004 Jul 5;14(13):3549-53. PMID:15177471

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