3vws
From Proteopedia
(Difference between revisions)
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| - | + | ==Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-107== | |
| - | + | <StructureSection load='3vws' size='340' side='right' caption='[[3vws]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | { | + | == Structural highlights == |
| + | <table><tr><td colspan='2'>[[3vws]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VWS FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=VWS:5-{[(4-CHLOROPHENYL)SULFONYL]AMINO}-2-METHYL-1-BENZOFURAN-3-CARBOXYLIC+ACID'>VWS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vws OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vws RCSB], [http://www.ebi.ac.uk/pdbsum/3vws PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We report a highly reproducible method to crystallize the RNA-dependent RNA polymerase (RdRp) domain of dengue virus serotype-3 (DENV-3), allowing structure refinement to 1.79 A resolution and revealing amino acids not seen previously. We also present a DENV-3 polymerase/inhibitor co-crystal structure at 2.1 A resolution. The inhibitor binds to the RdRp as a dimer and causes conformational changes in the protein. The improved crystallization conditions and new structural information should accelerate structure-based drug discovery. | ||
| - | + | Conformational flexibility of the dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor.,Noble CG, Lim SP, Chen YL, Liew CW, Yap L, Lescar J, Shi PY J Virol. 2013 Feb 13. PMID:23408636<ref>PMID:23408636</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Dengue virus 3]] | [[Category: Dengue virus 3]] | ||
[[Category: RNA-directed RNA polymerase]] | [[Category: RNA-directed RNA polymerase]] | ||
| - | [[Category: Lescar, J | + | [[Category: Lescar, J]] |
| - | [[Category: Noble, C G | + | [[Category: Noble, C G]] |
[[Category: Rna polymerase]] | [[Category: Rna polymerase]] | ||
[[Category: Rna-dependent rna polymerase]] | [[Category: Rna-dependent rna polymerase]] | ||
[[Category: Transferase-transferase inhibitor complex]] | [[Category: Transferase-transferase inhibitor complex]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
Revision as of 06:34, 21 December 2014
Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-107
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