1r8o
From Proteopedia
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| - | [[Image:1r8o.jpg|left|200px]] | + | [[Image:1r8o.jpg|left|200px]] |
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| - | '''Crystal structure of an unusual Kunitz-type trypsin inhibitor from Copaifera langsdorffii seeds''' | + | {{Structure |
| + | |PDB= 1r8o |SIZE=350|CAPTION= <scene name='initialview01'>1r8o</scene>, resolution 1.83Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Crystal structure of an unusual Kunitz-type trypsin inhibitor from Copaifera langsdorffii seeds''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1R8O is a [ | + | 1R8O is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Copaifera_langsdorffii Copaifera langsdorffii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R8O OCA]. |
==Reference== | ==Reference== | ||
| - | Three-dimensional structure of an unusual Kunitz (STI) type trypsin inhibitor from Copaifera langsdorffii., Krauchenco S, Nagem RA, da Silva JA, Marangoni S, Polikarpov I, Biochimie. 2004 Mar;86(3):167-72. PMID:[http:// | + | Three-dimensional structure of an unusual Kunitz (STI) type trypsin inhibitor from Copaifera langsdorffii., Krauchenco S, Nagem RA, da Silva JA, Marangoni S, Polikarpov I, Biochimie. 2004 Mar;86(3):167-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15134830 15134830] |
[[Category: Copaifera langsdorffii]] | [[Category: Copaifera langsdorffii]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: x-ray structure]] | [[Category: x-ray structure]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:48:21 2008'' |
Revision as of 11:48, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of an unusual Kunitz-type trypsin inhibitor from Copaifera langsdorffii seeds
Overview
The crystallographic structure of a novel trypsin inhibitor (CTI) from Copaifera langsdorffii is reported. The structure was solved by MIRAS procedure and refined to a crystallographic residual of 17.3% (R(free) = 20.3%) at 1.8 A resolution. Two isomorphous derivatives were obtained by quick cryo-soaking approach. CTI is the first structure of a member of Kunitz (STI) family formed by two noncovalently bound polypeptide chains and only one disulfide bridge. A standard Kunitz-type inhibitor has a single polypeptide chain and two disulfide bridges. Structural features granting CTI high inhibitory activity are discussed.
About this Structure
1R8O is a Protein complex structure of sequences from Copaifera langsdorffii. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of an unusual Kunitz (STI) type trypsin inhibitor from Copaifera langsdorffii., Krauchenco S, Nagem RA, da Silva JA, Marangoni S, Polikarpov I, Biochimie. 2004 Mar;86(3):167-72. PMID:15134830
Page seeded by OCA on Thu Mar 20 13:48:21 2008
