3vr0
From Proteopedia
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| - | + | ==Crystal structure of Pyrococcus furiosus PbaB, an archaeal proteasome activator== | |
| - | + | <StructureSection load='3vr0' size='340' side='right' caption='[[3vr0]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3vr0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus_dsm_3638 Pyrococcus furiosus dsm 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VR0 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3gaa|3gaa]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PF1142 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=186497 Pyrococcus furiosus DSM 3638])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vr0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vr0 RCSB], [http://www.ebi.ac.uk/pdbsum/3vr0 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Assembly of the eukaryotic 20S proteasome is an ordered process involving several proteins operating as proteasome assembly factors including PAC1-PAC2 but archaeal 20S proteasome subunits can spontaneously assemble into an active cylindrical architecture. Recent bioinformatic analysis identified archaeal PAC1-PAC2 homologs PbaA and PbaB. However, it remains unclear whether such assembly factor-like proteins play an indispensable role in orchestration of proteasome subunits in archaea. We revealed that PbaB forms a homotetramer and exerts a dual function as an ATP-independent proteasome activator and a molecular chaperone through its tentacle-like C-terminal segments. Our findings provide insights into molecular evolution relationships between proteasome activators and assembly factors. | ||
| - | + | An archaeal homolog of proteasome assembly factor functions as a proteasome activator.,Kumoi K, Satoh T, Murata K, Hiromoto T, Mizushima T, Kamiya Y, Noda M, Uchiyama S, Yagi H, Kato K PLoS One. 2013;8(3):e60294. doi: 10.1371/journal.pone.0060294. Epub 2013 Mar 21. PMID:23555947<ref>PMID:23555947</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Pyrococcus furiosus dsm 3638]] | [[Category: Pyrococcus furiosus dsm 3638]] | ||
| - | [[Category: Hiromoto, T | + | [[Category: Hiromoto, T]] |
| - | [[Category: Kamiya, Y | + | [[Category: Kamiya, Y]] |
| - | [[Category: Kato, K | + | [[Category: Kato, K]] |
| - | [[Category: Kumoi, K | + | [[Category: Kumoi, K]] |
| - | [[Category: Mizushima, T | + | [[Category: Mizushima, T]] |
| - | [[Category: Murata, K | + | [[Category: Murata, K]] |
| - | [[Category: Noda, M | + | [[Category: Noda, M]] |
| - | [[Category: Satoh, T | + | [[Category: Satoh, T]] |
| - | [[Category: Uchiyama, S | + | [[Category: Uchiyama, S]] |
| - | [[Category: Yagi, H | + | [[Category: Yagi, H]] |
[[Category: Proteasome]] | [[Category: Proteasome]] | ||
[[Category: Proteasome activator]] | [[Category: Proteasome activator]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
Revision as of 06:55, 21 December 2014
Crystal structure of Pyrococcus furiosus PbaB, an archaeal proteasome activator
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