3stq

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{{STRUCTURE_3stq| PDB=3stq | SCENE= }}
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==Hypothetical protein PA2703 Pseudomonas aeruginosa PAO1==
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===Hypothetical protein PA2703 Pseudomonas aeruginosa PAO1===
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<StructureSection load='3stq' size='340' side='right' caption='[[3stq]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
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{{ABSTRACT_PUBMED_22310046}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3stq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3STQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3STQ FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA2703 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3stq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3stq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3stq RCSB], [http://www.ebi.ac.uk/pdbsum/3stq PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In the competition for niches in natural resources, Pseudomonas aeruginosa utilizes the type VI secretion system to inject the toxic protein effector Tse2 into bacteria on cell-cell contact. The cytoplasm toxin immunity protein Tsi2 can neutralize Tse2 by physical interaction with the toxin, providing essential protection from toxin activity. Except for orthologues in P. aeruginosa, Tsi2 antitoxin does not share detectable sequence homology with known proteins in public databases. The mechanism underlying toxin neutralization by Tsi2 remains unknown. We report here the crystal structure of Tsi2 at 2.28 A resolution. Our structural and biophysical analyses demonstrate that the antitoxin adopts a previously unobserved superhelical conformation. Tsi2 is highly thermostable in the absence of the toxin in solution. Tsi2 assembles a dimer with 2-fold rotational symmetry, similar to that observed in other toxin-antitoxin systems. Dimerization is essential for the stable folding of Tsi2.
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==About this Structure==
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Crystal structure of Pseudomonas aeruginosa Tsi2 reveals a stably folded superhelical antitoxin.,Zou T, Yao X, Qin B, Zhang M, Cai L, Shang W, Svergun DI, Wang M, Cui S, Jin Q J Mol Biol. 2012 Apr 6;417(4):351-61. Epub 2012 Jan 30. PMID:22310046<ref>PMID:22310046</ref>
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[[3stq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3STQ OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:022310046</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Cui, S.]]
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[[Category: Cui, S]]
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[[Category: Jin, Q.]]
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[[Category: Jin, Q]]
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[[Category: Wang, M T.]]
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[[Category: Wang, M T]]
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[[Category: Zou, T T.]]
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[[Category: Zou, T T]]
[[Category: Coiled-coil]]
[[Category: Coiled-coil]]
[[Category: T6ss]]
[[Category: T6ss]]

Revision as of 07:12, 21 December 2014

Hypothetical protein PA2703 Pseudomonas aeruginosa PAO1

3stq, resolution 2.28Å

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