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1rcb
From Proteopedia
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| - | [[Image:1rcb.gif|left|200px]] | + | [[Image:1rcb.gif|left|200px]] |
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| - | '''CRYSTAL STRUCTURE OF HUMAN RECOMBINANT INTERLEUKIN-4 AT 2.25 ANGSTROMS RESOLUTION''' | + | {{Structure |
| + | |PDB= 1rcb |SIZE=350|CAPTION= <scene name='initialview01'>1rcb</scene>, resolution 2.25Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''CRYSTAL STRUCTURE OF HUMAN RECOMBINANT INTERLEUKIN-4 AT 2.25 ANGSTROMS RESOLUTION''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1RCB is a [ | + | 1RCB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RCB OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of human recombinant interleukin-4 at 2.25 A resolution., Wlodawer A, Pavlovsky A, Gustchina A, FEBS Lett. 1992 Aug 31;309(1):59-64. PMID:[http:// | + | Crystal structure of human recombinant interleukin-4 at 2.25 A resolution., Wlodawer A, Pavlovsky A, Gustchina A, FEBS Lett. 1992 Aug 31;309(1):59-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1511746 1511746] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: cytokine]] | [[Category: cytokine]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:49:38 2008'' |
Revision as of 11:49, 20 March 2008
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| , resolution 2.25Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF HUMAN RECOMBINANT INTERLEUKIN-4 AT 2.25 ANGSTROMS RESOLUTION
Contents |
Overview
The crystal structure of human recombinant interleukin-4 (IL-4) has been solved by multiple isomorphous replacement, and refined to an R factor of 0.218 at 2.25 A resolution. The molecule is a left-handed four-helix bundle with a short stretch of beta sheet. The structure bears close resemblance to other cytokines such as granulocyte-macrophage colony stimulating factor (GM-CSF). Although no sequence similarity of IL-4 to GM-CSF and other related cytokines has been previously postulated, structure-based alignment of IL-4 and GM-CSF revealed that the core of the molecules, including large parts of all four helices and extending over half of the molecule, has 30% sequence identity. This may have identified regions which are not only important to maintain structure, but could also play a role in receptor binding.
Disease
Known diseases associated with this structure: AIDS, slow progression to OMIM:[147781], Atopy, susceptibility to OMIM:[147781]
About this Structure
1RCB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of human recombinant interleukin-4 at 2.25 A resolution., Wlodawer A, Pavlovsky A, Gustchina A, FEBS Lett. 1992 Aug 31;309(1):59-64. PMID:1511746
Page seeded by OCA on Thu Mar 20 13:49:38 2008
