1rcw
From Proteopedia
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| - | [[Image:1rcw.jpg|left|200px]] | + | [[Image:1rcw.jpg|left|200px]] |
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| - | '''Crystal structure of CT610 from Chlamydia trachomatis''' | + | {{Structure |
| + | |PDB= 1rcw |SIZE=350|CAPTION= <scene name='initialview01'>1rcw</scene>, resolution 2.50Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=FE:FE (III) ION'>FE</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= CT610 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=813 Chlamydia trachomatis]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of CT610 from Chlamydia trachomatis''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1RCW is a [ | + | 1RCW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Chlamydia_trachomatis Chlamydia trachomatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RCW OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of the Chlamydia protein CADD reveals a redox enzyme that modulates host cell apoptosis., Schwarzenbacher R, Stenner-Liewen F, Liewen H, Robinson H, Yuan H, Bossy-Wetzel E, Reed JC, Liddington RC, J Biol Chem. 2004 Jul 9;279(28):29320-4. Epub 2004 Apr 15. PMID:[http:// | + | Structure of the Chlamydia protein CADD reveals a redox enzyme that modulates host cell apoptosis., Schwarzenbacher R, Stenner-Liewen F, Liewen H, Robinson H, Yuan H, Bossy-Wetzel E, Reed JC, Liddington RC, J Biol Chem. 2004 Jul 9;279(28):29320-4. Epub 2004 Apr 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15087448 15087448] |
[[Category: Chlamydia trachomatis]] | [[Category: Chlamydia trachomatis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: redox enzyme]] | [[Category: redox enzyme]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:49:53 2008'' |
Revision as of 11:49, 20 March 2008
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| , resolution 2.50Å | |||||||
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| Ligands: | |||||||
| Gene: | CT610 (Chlamydia trachomatis) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of CT610 from Chlamydia trachomatis
Overview
The Chlamydia protein CADD (Chlamydia protein associating with death domains) has been implicated in the modulation of host cell apoptosis via binding to the death domains of tumor necrosis factor family receptors. Transfection of CADD into mammalian cells induces apoptosis. Here we present the CADD crystal structure, which reveals a dimer of seven-helix bundles. Each bundle contains a di-iron center adjacent to an internal cavity, forming an active site similar to that of methane mono-oxygenase hydrolase. We further show that CADD mutants lacking critical metal-coordinating residues are substantially less effective in inducing apoptosis but retain their ability to bind to death domains. We conclude that CADD is a novel redox protein toxin unique to Chlamydia species and propose that both its redox activity and death domain binding ability are required for its biological activity.
About this Structure
1RCW is a Single protein structure of sequence from Chlamydia trachomatis. Full crystallographic information is available from OCA.
Reference
Structure of the Chlamydia protein CADD reveals a redox enzyme that modulates host cell apoptosis., Schwarzenbacher R, Stenner-Liewen F, Liewen H, Robinson H, Yuan H, Bossy-Wetzel E, Reed JC, Liddington RC, J Biol Chem. 2004 Jul 9;279(28):29320-4. Epub 2004 Apr 15. PMID:15087448
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