3u0r

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{{STRUCTURE_3u0r| PDB=3u0r | SCENE= }}
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==Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules==
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===Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules===
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<StructureSection load='3u0r' size='340' side='right' caption='[[3u0r]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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{{ABSTRACT_PUBMED_22334682}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3u0r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U0R FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">API5, MIG8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u0r RCSB], [http://www.ebi.ac.uk/pdbsum/3u0r PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Apoptosis inhibitor 5 (API5) is an anti-apoptotic protein that is up-regulated in various cancer cells. Here, we present the crystal structure of human API5. API5 exhibits an elongated all alpha-helical structure. The N-terminal half of API5 is similar to the HEAT repeat and the C-terminal half is similar to the ARM (Armadillo-like) repeat. HEAT and ARM repeats have been implicated in protein-protein interactions, suggesting that the cellular roles of API5 may be to mediate protein-protein interactions. Various components of multiprotein complexes have been identified as API5-interacting protein partners, suggesting that API5 may act as a scaffold for multiprotein complexes. API5 exists as a monomer, and the functionally important heptad leucine repeat does not exhibit the predicted a dimeric leucine zipper. Additionally, Lys-251, which can be acetylated in cells, plays important roles in the inhibition of apoptosis under serum deprivation conditions. The acetylation of this lysine also affects the stability of API5 in cells.
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==Function==
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Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules.,Han BG, Kim KH, Lee SJ, Jeong KC, Cho JW, Noh KH, Kim TW, Kim SJ, Yoon HJ, Suh SW, Lee S, Lee BI J Biol Chem. 2012 Mar 30;287(14):10727-37. doi: 10.1074/jbc.M111.317594. Epub, 2012 Feb 12. PMID:22334682<ref>PMID:22334682</ref>
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[[http://www.uniprot.org/uniprot/API5_HUMAN API5_HUMAN]] Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.<ref>PMID:10780674</ref> <ref>PMID:17112319</ref> <ref>PMID:19387494</ref>
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[3u0r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0R OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022334682</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cho, J W.]]
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[[Category: Cho, J W]]
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[[Category: Han, B G.]]
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[[Category: Han, B G]]
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[[Category: Jeong, K C.]]
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[[Category: Jeong, K C]]
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[[Category: Kim, K H.]]
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[[Category: Kim, K H]]
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[[Category: Kim, T W.]]
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[[Category: Kim, T W]]
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[[Category: Lee, B I.]]
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[[Category: Lee, B I]]
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[[Category: Lee, S H.]]
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[[Category: Lee, S H]]
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[[Category: Noh, K H.]]
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[[Category: Noh, K H]]
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[[Category: Suh, S W.]]
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[[Category: Suh, S W]]
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[[Category: Yoon, H J.]]
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[[Category: Yoon, H J]]
[[Category: Apoptosis inhibitor]]
[[Category: Apoptosis inhibitor]]
[[Category: Armadillo repeat]]
[[Category: Armadillo repeat]]
[[Category: Heat repeat]]
[[Category: Heat repeat]]
[[Category: Lysine acetylation]]
[[Category: Lysine acetylation]]

Revision as of 07:33, 21 December 2014

Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules

3u0r, resolution 2.50Å

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