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3u9g

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{{STRUCTURE_3u9g| PDB=3u9g | SCENE= }}
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==Crystal structure of the Zinc finger antiviral protein==
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===Crystal structure of the Zinc finger antiviral protein===
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<StructureSection load='3u9g' size='340' side='right' caption='[[3u9g]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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{{ABSTRACT_PUBMED_22407013}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3u9g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U9G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U9G FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Zc3hav1, Zap ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u9g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u9g RCSB], [http://www.ebi.ac.uk/pdbsum/3u9g PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Zinc-finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses, such as HIV-1, by targeting viral mRNA for degradation. How ZAP recognizes its target RNA has been unclear. Here we report the crystal structure of the N-terminal domain of rat ZAP (NZAP225), the major functional domain. The overall structure of NZAP225 resembles a tractor, with four zinc-finger motifs located at the bottom. Structural and functional analyses identified multiple positively charged residues and two putative RNA-binding cavities forming a large putative RNA-binding cleft. ZAP molecules interact to form a dimer that binds to a ZAP-responsive RNA molecule containing two ZAP-binding modules. These results provide insights into how ZAP binds specifically to complex target RNA.
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==About this Structure==
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Structure of N-terminal domain of ZAP indicates how a zinc-finger protein recognizes complex RNA.,Chen S, Xu Y, Zhang K, Wang X, Sun J, Gao G, Liu Y Nat Struct Mol Biol. 2012 Mar 11;19(4):430-5. doi: 10.1038/nsmb.2243. PMID:22407013<ref>PMID:22407013</ref>
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[[3u9g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U9G OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:022407013</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Chen, S.]]
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[[Category: Chen, S]]
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[[Category: Gao, G.]]
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[[Category: Gao, G]]
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[[Category: Liu, Y.]]
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[[Category: Liu, Y]]
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[[Category: Sun, J.]]
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[[Category: Sun, J]]
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[[Category: Wang, X.]]
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[[Category: Wang, X]]
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[[Category: Xu, Y.]]
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[[Category: Xu, Y]]
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[[Category: Zhang, K.]]
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[[Category: Zhang, K]]
[[Category: Antiviral protein]]
[[Category: Antiviral protein]]
[[Category: Zinc finger protein]]
[[Category: Zinc finger protein]]

Revision as of 07:35, 21 December 2014

Crystal structure of the Zinc finger antiviral protein

3u9g, resolution 1.80Å

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